The study of molecular evolution at the level of protein-coding genes often entails comparing
large datasets of sequences to infer their evolutionary relationships. Despite the importance …

The recurrent repeats having conserved stretches of amino acids exists across all domains
of life. Subsequent repetition of single sequence motif and the number and length of the …

Abstract The interface of protein structural biology, protein biophysics, molecular evolution,
and molecular population genetics forms the foundations for a mechanistic understanding of …

How do proteins evolve? How do changes in sequence mediate changes in protein
structure, and in turn in function? This question has multiple angles, ranging from …

Animal toxins are of interest to a wide range of scientists, due to their numerous applications
in pharmacology, neurology, hematology, medicine, and drug research. This, and to a lesser …

Background The plant immune system is innate and encoded in the germline. Using it
efficiently, plants are capable of recognizing a diverse range of rapidly evolving pathogens …

Contemporary protein architectures can be regarded as molecular fossils, historical imprints
that mark important milestones in the history of life. Whereas sequences change at a …

Intrinsic disorder is more abundant in eukaryotic than prokaryotic proteins. Methods
predicting intrinsic disorder are based on the amino acid sequence of a protein. Therefore …

Many insect genomes have been sequenced and the innate immune responses of several
species have been studied by transcriptomics, inviting the comparative analysis of immunity …

The current outbreak of coronavirus disease-2019 (COVID-19) caused by SARS-CoV-2
poses unparalleled challenges to global public health. SARS-CoV-2 is a Betacoronavirus …