Colorectal cancer (CRC) is the third most common cancer and the fourth most common
cause of cancer-related death. Most cases of CRC are detected in Western countries, with its …

For the many years, the central dogma of molecular biology has been that RNA functions
mainly as an informational intermediate between a DNA sequence and its encoded protein …

The GENCODE Consortium aims to identify all gene features in the human genome using a
combination of computational analysis, manual annotation, and experimental validation …

Research over the past decade has suggested important roles for pseudogenes in
physiology and disease. In vitro experiments demonstrated that pseudogenes contribute to …

Background Pseudogenes have long been considered as nonfunctional genomic
sequences. However, recent evidence suggests that many of them might have some form of …

Pseudogene transcripts can provide a novel tier of gene regulation through generation of
endogenous siRNAs or miRNA-binding sites. Characterization of pseudogene expression …

Although ignored in the past, with the recent deepening of research, significant progress has
been made in the field of non-coding RNAs (ncRNAs). Accumulating evidence has revealed …

Pseudogenes are ubiquitous and abundant in genomes. Pseudogenes were once called
“genomic fossils” and treated as “junk DNA” several years. Nevertheless, it has been …

Functional genomics has provided evidence that the human genome transcribes a large
number of non-coding genes in addition to protein-coding genes, including microRNAs and …

Pseudogenes were initially regarded as non-functional genomic fossils resulted from
inactivating gene mutations during evolution. However, later studies revealed that they play …