Hepatocellular carcinoma (HCC) arises from hepatocytes through the sequential
accumulation of multiple genomic and epigenomic alterations resulting from Darwinian …

Locoregional therapies are commonly used to treat patients with hepatocellular carcinoma. It
has been noted for many years that locoregional therapies may have additional systemic …

Tumor-associated macrophages (TAMs) are correlated with the progression of prostatic
adenocarcinoma (PCa). The mechanistic basis of this correlation and therapeutic strategies …

Background & Aims Although the tumor microenvironment plays an important role in tumor
growth, it is not fully understood what role hepatic stellate cells (HSCs) play in the …

During aging, progenitor cells acquire mutations, which may generate clones that colonize
the surrounding tissue. By middle age, normal human tissues, including the esophageal …

Metabolic reprogramming is critically involved in the development and progression of
cancer. In particular, lipid metabolism has been investigated as a source of energy, micro …

Metabolic reprogramming for adaptation to the local environment has been recognized as a
hallmark of cancer. Although alterations in fatty acid (FA) metabolism in cancer cells have …

Chronic liver disease and primary liver cancer are a massive global problem, with a future
increase in incidences predicted. The most prevalent form of primary liver cancer …

Hepatocellular carcinoma (HCC) is a primary malignancy of the liver with a high worldwide
prevalence and poor prognosis. Researches are urgently needed on its molecular …

EFSA was asked for a scientific opinion on the risks to public health related to the presence
of N‐nitrosamines (N‐NAs) in food. The risk assessment was confined to those 10 …