Brain metastases signify a deleterious milestone in the progression of several advanced
cancers, predominantly originating from lung, breast and melanoma malignancies, with a …

Objective Melanoma has a high degree of central nervous system tropism, and there are
many treatment modalities for melanoma brain metastases (MBM). The efficacy and toxicity …

Significant advancements have been made in the treatment of advanced melanoma with the
use of immune checkpoint inhibitors, novel immunotherapies, and BRAF/MEK-targeted …

Background Conjunctival melanoma is a rare type of ocular melanoma, which is prone to
local recurrence and metastasis and can lead to patient death. Novel therapeutic strategies …

Background Recent therapeutic advances in metastatic melanoma have led to improved
overall survival (OS) rates, with consequently an increased incidence of brain metastases …

Brain metastases from melanoma are no longer uniformly associated with dismal outcomes.
Impressive tumor tissue-based (craniotomy) translational research has consistently shown …

Melanoma brain metastases present a major challenge in cancer treatment and reduce
overall survival despite advances in managing primary melanoma. Immune checkpoint …

Many studies have reported the combination of radiosurgery and immune checkpoint
inhibitors (ICI) in the treatment of brain metastasis, but these studies have not reached a …

Background Melanoma brain metastasis (MBM) has a poor prognosis, although recent
treatments, including immune checkpoint inhibitors and targeted therapy, have improved the …

Background This study aimed to explore the mechanism of parthenolide in inhibiting
melanoma metastasis through network pharmacology and cell experiment. Materials and …