Aging is accompanied by remodeling of the immune system. With time, this leads to a
decline in immune efficacy, resulting in increased vulnerability to infectious diseases …

Background Recently, the hallmarks of aging were updated to include dysbiosis, disabled
macroautophagy, and chronic inflammation. In particular, the low-grade chronic …

Although death is inevitable, individuals have long sought to alter the course of the ageing
process. Indeed, ageing has proved to be modifiable; by intervening in biological systems …

Acute inflammation is a physiological response to injury or infection, with a cascade of steps
that ultimately lead to the recruitment of immune cells to clear invading pathogens and heal …

Senescent cell accumulation has been observed in age-associated diseases including
cardiovascular diseases. Senescent cells lack proliferative capacity and secrete senescence …

Metformin is sometimes proposed to be an “anti-aging” drug, based on preclinical
experiments with lower-order organisms and numerous retrospective data on beneficial …

Ribosomopathies are a diverse subset of diseases caused by reduced expression of, or
mutations in, factors necessary for making ribosomes, the protein translation machinery in …

The COVID-19 pandemic serves as a potent reminder that older people are at very high risk
of adverse outcomes from infectious disease because of comorbidities associated with …

With aging, the kidney undergoes inexorable and progressive changes in structural and
functional performance. These aging‐related alterations are more obvious and serious in …

Up to 85% of adult cancer survivors and 99% of adult survivors of childhood cancer live with
an accumulation of chronic conditions, frailty, and/or cognitive impairments resulting from …