On the perils of poor editing: regulation of peptide loading by HLA-DQ and H2-A molecules associated with celiac disease and type 1 diabetes
R Busch, A De Riva, AV Hadjinicolaou… - Expert reviews in …, 2012 - cambridge.org
This review discusses mechanisms that link allelic variants of major histocompatibility
complex (MHC) class II molecules (MHCII) to immune pathology. We focus on HLA (human …
complex (MHC) class II molecules (MHCII) to immune pathology. We focus on HLA (human …
An insertion mutant in DQA1* 0501 restores susceptibility to HLA-DM: implications for disease associations
T Hou, H Macmillan, Z Chen, CL Keech… - The Journal of …, 2011 - journals.aai.org
Abstract HLA-DM (DM) catalyzes CLIP release, stabilizes MHC class II molecules, and edits
the peptide repertoire presented by class II. Impaired DM function may have profound effects …
the peptide repertoire presented by class II. Impaired DM function may have profound effects …
Epitope selection for HLA-DQ2 presentation: implications for celiac disease and viral defense
We have reported that the major histocompatibility molecule HLA-DQ2 (DQA1* 05:
01/DQB1* 02: 01)(DQ2) is relatively resistant to HLA-DM (DM), a peptide exchange catalyst …
01/DQB1* 02: 01)(DQ2) is relatively resistant to HLA-DM (DM), a peptide exchange catalyst …
Accelerated turnover of MHC class II molecules in nonobese diabetic mice is developmentally and environmentally regulated in vivo and dispensable for …
A De Riva, MC Varley, LJ Bluck, A Cooke… - The Journal of …, 2013 - journals.aai.org
Abstract The H2-A g7 (A g7) MHC class II (MHCII) allele is required for type 1 diabetes (T1D)
in NOD mice. A g7 not only has a unique peptide-binding profile, it was reported to exhibit …
in NOD mice. A g7 not only has a unique peptide-binding profile, it was reported to exhibit …
γδ T cells recognize the insulin B: 9–23 peptide antigen when it is dimerized through thiol oxidation
MK Aydintug, L Zhang, C Wang, D Liang… - Molecular …, 2014 - Elsevier
Abstract The insulin peptide B: 9–23 is a natural antigen in the non-obese diabetic (NOD)
mouse model of type 1 diabetes (T1D). In addition to αβ T cells and B cells, γδ T cells …
mouse model of type 1 diabetes (T1D). In addition to αβ T cells and B cells, γδ T cells …
[HTML][HTML] Comparison of transduction efficiency among various lentiviruses containing GFP reporter in bone marrow hematopoietic stem cell transplantation
HIV-derived lentiviral vectors have been used widely to transduce non-dividing cells, such
as hematopoietic stem cells (HSCs), in the setting of gene therapy. In this study, we …
as hematopoietic stem cells (HSCs), in the setting of gene therapy. In this study, we …
[HTML][HTML] MHC Class II Protein Turnover In vivo and Its Relevance for Autoimmunity in Non-Obese Diabetic Mice
A De Riva, R Busch - Frontiers in Immunology, 2013 - frontiersin.org
Major histocompatibility complex class II (MHCII) proteins are loaded with endosomal
peptides and reside at the surface of antigen-presenting cells (APCs) for a time before being …
peptides and reside at the surface of antigen-presenting cells (APCs) for a time before being …
[HTML][HTML] Immunological Basis for Rapid Progression of Diabetes in Older NOD Mouse Recipients Post BM-HSC Transplantation
N Wang, N Rajasekaran, T Hou, C Macaubas… - Plos one, 2015 - journals.plos.org
Type I diabetes (T1D), mediated by autoreactive T cell destruction of insulin-producing islet
beta cells, has been treated with bone marrow-derived hematopoietic stem cell (BM-HSC) …
beta cells, has been treated with bone marrow-derived hematopoietic stem cell (BM-HSC) …
[HTML][HTML] Transgene expression in various organs post BM-HSC transplantation
N Wang, N Rajasekaran, T Hou, ED Mellins - Stem cell research, 2014 - Elsevier
Gene therapy mediated by bone marrow-derived hematopoietic stem cells (BM-HSC) has
been widely used in treating genetic deficiencies in both pre-clinical and clinical settings …
been widely used in treating genetic deficiencies in both pre-clinical and clinical settings …
Quality control of HLA-DR molecules by the lysosomal aspartyl protease, cathepsin D
N Shah, S McDonald, CTA Parker, RWM Robinson… - bioRxiv, 2020 - biorxiv.org
Major histocompatibility complex class II (MHCII) molecules display peptides on antigen-
presenting cells (APCs) for inspection by CD4+ T cells. MHCII surface levels and life span …
presenting cells (APCs) for inspection by CD4+ T cells. MHCII surface levels and life span …