Abstract Melatonin (5‐methoxy‐N‐acetyltryptamine) binds with high affinity and specificity to
membrane receptors. Several receptor subtypes exist in different species, of which the …

Melatonin, a neurohormone secreted by the pineal gland and regulated by the
suprachiasmatic nucleus (SCN) of the hypothalamus, is synthesized and directly released …

The labeled ligand commonly employed in competition binding studies for melatonin
receptor ligands, 2‐[125I] iodomelatonin, showed slow dissociation with different half‐lives …

Targeted covalent inhibitors hold promise for drug discovery, particularly for kinases.
Targeting the catalytic lysine of epidermal growth factor receptor (EGFR) has attracted …

The residence time (RT), the time for which a drug remains bound to its biological target, is a
critical parameter for drug design. The prediction of this key kinetic property has been …

Introduction The neurohormone melatonin (N-acetyl-5-methoxytryptamine) regulates
circadian rhythms exerting a variety of effects in the central nervous system and in periphery …

The bone immune microenvironment can influence the occurrence and progression of bone
defects. To date, research on promoting macrophage M2 polarization to improve bone injury …

The photoreceptor rhodopsin (Rho) becomes active when a tethered inverse agonist ligand
(11CR) is photoconverted to an agonist (ATR). The ligand-binding pocket of inactive …