[HTML][HTML] Virus-like particles: preparation, immunogenicity and their roles as nanovaccines and drug nanocarriers
S Nooraei, H Bahrulolum, ZS Hoseini… - Journal of …, 2021 - Springer
Virus-like particles (VLPs) are virus-derived structures made up of one or more different
molecules with the ability to self-assemble, mimicking the form and size of a virus particle but …
molecules with the ability to self-assemble, mimicking the form and size of a virus particle but …
Virus-like particles in vaccine development
A Roldão, MCM Mellado, LR Castilho… - Expert review of …, 2010 - Taylor & Francis
Virus-like particles (VLPs) are multiprotein structures that mimic the organization and
conformation of authentic native viruses but lack the viral genome, potentially yielding safer …
conformation of authentic native viruses but lack the viral genome, potentially yielding safer …
Virus-like particle vaccines: immunology and formulation for clinical translation
B Donaldson, Z Lateef, GF Walker… - Expert review of …, 2018 - Taylor & Francis
Introduction: Virus-like particle (VLP) vaccines face significant challenges in their translation
from laboratory models, to routine clinical administration. While some VLP vaccines thrive …
from laboratory models, to routine clinical administration. While some VLP vaccines thrive …
Current challenges in biotherapeutic particles manufacturing
Introduction: The development of novel complex biotherapeutics led to new challenges in
biopharmaceutical industry. The potential of these particles has been demonstrated by the …
biopharmaceutical industry. The potential of these particles has been demonstrated by the …
Large-scale production and purification of VLP-based vaccines
Virus-like particles (VLPs) hold tremendous potential as vaccine candidates. These
innovative biopharmaceuticals present the remarkable advantages of closely mimicking the …
innovative biopharmaceuticals present the remarkable advantages of closely mimicking the …
Protein production using the baculovirus‐insect cell expression system
A Contreras‐Gómez, A Sánchez‐Mirón… - Biotechnology …, 2014 - Wiley Online Library
The baculovirus‐insect cell expression system is widely used in producing recombinant
proteins. This review is focused on the use of this expression system in developing …
proteins. This review is focused on the use of this expression system in developing …
[PDF][PDF] Advances and challenges in enveloped virus-like particle (VLP)-based vaccines
S Dai, H Wang, F Deng - Journal of …, 2018 - immunologyresearchjournal.com
Virus-like particles (VLPs) are highly organized particles that self-assemble from viral
structural proteins. Like parental viruses, VLPs can be either non-enveloped or enveloped …
structural proteins. Like parental viruses, VLPs can be either non-enveloped or enveloped …
[HTML][HTML] Separation of virus-like particles and extracellular vesicles by flow-through and heparin affinity chromatography
K Reiter, PP Aguilar, V Wetter, P Steppert… - … of Chromatography A, 2019 - Elsevier
Separation of enveloped virus-like particles from other extracellular vesicles is a challenging
separation problem due to the similarity of these bionanoparticles. Without simple and …
separation problem due to the similarity of these bionanoparticles. Without simple and …
Improved virus purification processes for vaccines and gene therapy
P Nestola, C Peixoto, RRJS Silva… - Biotechnology and …, 2015 - Wiley Online Library
The downstream processing of virus particles for vaccination or gene therapy is becoming a
critical bottleneck as upstream titers keep improving. Moreover, the growing pressure to …
critical bottleneck as upstream titers keep improving. Moreover, the growing pressure to …
Use of baculovirus expression system for generation of virus-like particles: successes and challenges
F Liu, X Wu, L Li, Z Liu, Z Wang - Protein expression and purification, 2013 - Elsevier
The baculovirus expression system (BES) has been one of the versatile platforms for the
production of recombinant proteins requiring multiple post-translational modifications, such …
production of recombinant proteins requiring multiple post-translational modifications, such …