The ESCRT complexes and associated proteins comprise a major pathway for the
lysosomal degradation of transmembrane proteins and are critical for receptor …

The release of retrovirus particles from the infected cell is greatly stimulated by short motifs,
known as “late” or “L” domains, present within the Gag precursor protein. Three distinct …

Intraluminal vesicles of multivesicular endosomes are either sorted for cargo degradation
into lysosomes or secreted as exosomes into the extracellular milieu. The mechanisms …

The release of enveloped viruses from infected cells often requires a virally encoded activity,
termed a late-budding domain (L domain), encoded by essential PTAP, PPXY, or YPDL …

Cargo partitioning into intralumenal vesicles (ILVs) of multivesicular endosomes underlies
such cellular processes as receptor downregulation, viral budding, and biogenesis of …

ESCRT complexes form the main machinery driving protein sorting from endosomes to
lysosomes. Currently, the picture regarding assembly of ESCRTs on endosomes is …

The ESCRT (endosomal sorting complex required for transport) complexes and associated
proteins mediate membrane scission reactions, such as multivesicular body formation, the …

Publisher Summary This chapter describes the assembly, release, and maturation of human
immunodeficiency virus type 1 (HIV-1). The HIV‐1 replication cycle has the potential to …

The budding of many enveloped RNA viruses, including human immunodeficiency virus
type 1 (HIV-1), requires some of the same cellular machinery as vesicle formation at the …

Considerable success has been achieved in the treatment of HIV-1 infection, and more than
two-dozen antiretroviral drugs are available targeting several distinct steps in the viral …