The interplay between m6A RNA methylation and noncoding RNA in cancer
S Ma, C Chen, X Ji, J Liu, Q Zhou, G Wang… - Journal of hematology & …, 2019 - Springer
Abstract N6-methyladenosine (m6A) methylation, one of the most common RNA
modifications, has been reported to execute important functions that affect normal life …
modifications, has been reported to execute important functions that affect normal life …
microRNA strand selection: Unwinding the rules
Abstract microRNAs (miRNAs) play a central role in the regulation of gene expression by
targeting specific mRNAs for degradation or translational repression. Each miRNA is post …
targeting specific mRNAs for degradation or translational repression. Each miRNA is post …
A structural view of miRNA biogenesis and function
AL Leitão, FJ Enguita - Non-coding RNA, 2022 - mdpi.com
Micro-RNAs (miRNAs) are a class of non-coding RNAs (ncRNAs) that act as post-
transcriptional regulators of gene expression. Since their discovery in 1993, they have been …
transcriptional regulators of gene expression. Since their discovery in 1993, they have been …
Anatomy of four human Argonaute proteins
K Nakanishi - Nucleic acids research, 2022 - academic.oup.com
MicroRNAs (miRNAs) bind to complementary target RNAs and regulate their gene
expression post-transcriptionally. These non-coding regulatory RNAs become functional …
expression post-transcriptionally. These non-coding regulatory RNAs become functional …
Structural basis for piRNA targeting
TA Anzelon, S Chowdhury, SM Hughes, Y Xiao… - Nature, 2021 - nature.com
PIWI proteins use PIWI-interacting RNAs (piRNAs) to identify and silence transposable
elements and thereby maintain genome integrity between metazoan generations. The …
elements and thereby maintain genome integrity between metazoan generations. The …
Argonaute proteins: from structure to function in development and pathological cell fate determination
M Müller, F Fazi, C Ciaudo - Frontiers in Cell and Developmental …, 2020 - frontiersin.org
The highly conserved Argonaute protein family members play a central role in the regulation
of gene expression networks, orchestrating the establishment and the maintenance of cell …
of gene expression networks, orchestrating the establishment and the maintenance of cell …
The role of m6A epigenetic modifications in tumor coding and non-coding RNA processing
T Wen, T Li, Y Xu, Y Zhang, H Pan, Y Wang - Cell Communication and …, 2023 - Springer
Background Epigenetic modifications of RNA significantly contribute to the regulatory
processes in tumors and have, thus, received considerable attention. The m6A modification …
processes in tumors and have, thus, received considerable attention. The m6A modification …
Structural basis for RNA slicing by a plant Argonaute
Argonaute (AGO) proteins use small RNAs to recognize transcripts targeted for silencing in
plants and animals. Many AGOs cleave target RNAs using an endoribonuclease activity …
plants and animals. Many AGOs cleave target RNAs using an endoribonuclease activity …
Structure and noncanonical Cdk8 activation mechanism within an Argonaute-containing Mediator kinase module
The Cdk8 kinase module (CKM) in Mediator, comprising Med13, Med12, CycC, and Cdk8,
regulates RNA polymerase II transcription through kinase-dependent and-independent …
regulates RNA polymerase II transcription through kinase-dependent and-independent …
[HTML][HTML] A specific type of Argonaute phosphorylation regulates binding to microRNAs during C. elegans development
Argonaute proteins are at the core of the microRNA-mediated gene silencing pathway
essential for animals. In C. elegans, the microRNA-specific Argonautes ALG-1 and ALG-2 …
essential for animals. In C. elegans, the microRNA-specific Argonautes ALG-1 and ALG-2 …