Neutrophilic inflammation in asthma and association with disease severity

A Ray, JK Kolls - Trends in immunology, 2017 - cell.com
Asthma is a chronic inflammatory disorder of the airways. While the local infiltration of
eosinophils and mast cells, and their role in the disease have long been recognized …

Cell death in the lung: the apoptosis–necroptosis axis

M Sauler, IS Bazan, PJ Lee - Annual review of physiology, 2019 - annualreviews.org
Regulated cell death is a major mechanism to eliminate damaged, infected, or superfluous
cells. Previously, apoptosis was thought to be the only regulated cell death mechanism; …

Association of clonal hematopoiesis with chronic obstructive pulmonary disease

PG Miller, D Qiao, J Rojas-Quintero… - Blood, The Journal …, 2022 - ashpublications.org
Chronic obstructive pulmonary disease (COPD) is associated with age and smoking, but
other determinants of the disease are incompletely understood. Clonal hematopoiesis of …

[HTML][HTML] High IFN-γ and low SLPI mark severe asthma in mice and humans

M Raundhal, C Morse, A Khare… - The Journal of …, 2015 - Am Soc Clin Investig
Severe asthma (SA) is a challenge to control, as patients are not responsive to high doses of
systemic corticosteroids (CS). In contrast, mild-moderate asthma (MMA) is responsive to low …

Chronic obstructive pulmonary disease: molecular and cellularmechanisms

PJ Barnes, SD Shapiro… - European Respiratory …, 2003 - Eur Respiratory Soc
Chronic obstructive pulmonary disease is a leading cause of death and disability, but has
only recently been extensively explored from a cellular and molecular perspective. There is …

[HTML][HTML] Experimental animal models for COPD: a methodological review

V Ghorani, MH Boskabady, MR Khazdair… - Tobacco induced …, 2017 - Springer
Introduction Chronic obstructive pulmonary disease (COPD) is a progressive disorder that
makes the breathing difficult and is characterized by pathological conditions ranging from …

Combined pulmonary fibrosis and emphysema: a distinct underrecognised entity

V Cottin, H Nunes, PY Brillet, P Delaval… - European …, 2005 - Eur Respiratory Soc
The syndrome resulting from combined pulmonary fibrosis and emphysema has not been
comprehensively described. The current authors conducted a retrospective study of 61 …

Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction

KF Chung, IM Adcock - European Respiratory Journal, 2008 - Eur Respiratory Soc
Chronic obstructive pulmonary disease is a leading global cause of morbidity and mortality
that is characterised by inexorable deterioration of small airways obstruction with …

Mediators of chronic obstructive pulmonary disease

PJ Barnes - Pharmacological reviews, 2004 - ASPET
Chronic obstructive pulmonary disease (COPD) is a major and increasing global health
problem that is now a leading cause of death. COPD is associated with a chronic …

Smoking-dependent reprogramming of alveolar macrophage polarization: implication for pathogenesis of chronic obstructive pulmonary disease

R Shaykhiev, A Krause, J Salit… - The Journal of …, 2009 - journals.aai.org
When exposed to a specific microenvironment, macrophages acquire either M1-or M2-
polarized phenotypes associated with inflammation and tissue remodeling, respectively …