Neutrophilic inflammation in asthma and association with disease severity
Asthma is a chronic inflammatory disorder of the airways. While the local infiltration of
eosinophils and mast cells, and their role in the disease have long been recognized …
eosinophils and mast cells, and their role in the disease have long been recognized …
Cell death in the lung: the apoptosis–necroptosis axis
Regulated cell death is a major mechanism to eliminate damaged, infected, or superfluous
cells. Previously, apoptosis was thought to be the only regulated cell death mechanism; …
cells. Previously, apoptosis was thought to be the only regulated cell death mechanism; …
Association of clonal hematopoiesis with chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD) is associated with age and smoking, but
other determinants of the disease are incompletely understood. Clonal hematopoiesis of …
other determinants of the disease are incompletely understood. Clonal hematopoiesis of …
[HTML][HTML] High IFN-γ and low SLPI mark severe asthma in mice and humans
M Raundhal, C Morse, A Khare… - The Journal of …, 2015 - Am Soc Clin Investig
Severe asthma (SA) is a challenge to control, as patients are not responsive to high doses of
systemic corticosteroids (CS). In contrast, mild-moderate asthma (MMA) is responsive to low …
systemic corticosteroids (CS). In contrast, mild-moderate asthma (MMA) is responsive to low …
Chronic obstructive pulmonary disease: molecular and cellularmechanisms
PJ Barnes, SD Shapiro… - European Respiratory …, 2003 - Eur Respiratory Soc
Chronic obstructive pulmonary disease is a leading cause of death and disability, but has
only recently been extensively explored from a cellular and molecular perspective. There is …
only recently been extensively explored from a cellular and molecular perspective. There is …
[HTML][HTML] Experimental animal models for COPD: a methodological review
V Ghorani, MH Boskabady, MR Khazdair… - Tobacco induced …, 2017 - Springer
Introduction Chronic obstructive pulmonary disease (COPD) is a progressive disorder that
makes the breathing difficult and is characterized by pathological conditions ranging from …
makes the breathing difficult and is characterized by pathological conditions ranging from …
Combined pulmonary fibrosis and emphysema: a distinct underrecognised entity
The syndrome resulting from combined pulmonary fibrosis and emphysema has not been
comprehensively described. The current authors conducted a retrospective study of 61 …
comprehensively described. The current authors conducted a retrospective study of 61 …
Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction
Chronic obstructive pulmonary disease is a leading global cause of morbidity and mortality
that is characterised by inexorable deterioration of small airways obstruction with …
that is characterised by inexorable deterioration of small airways obstruction with …
Mediators of chronic obstructive pulmonary disease
PJ Barnes - Pharmacological reviews, 2004 - ASPET
Chronic obstructive pulmonary disease (COPD) is a major and increasing global health
problem that is now a leading cause of death. COPD is associated with a chronic …
problem that is now a leading cause of death. COPD is associated with a chronic …
Smoking-dependent reprogramming of alveolar macrophage polarization: implication for pathogenesis of chronic obstructive pulmonary disease
R Shaykhiev, A Krause, J Salit… - The Journal of …, 2009 - journals.aai.org
When exposed to a specific microenvironment, macrophages acquire either M1-or M2-
polarized phenotypes associated with inflammation and tissue remodeling, respectively …
polarized phenotypes associated with inflammation and tissue remodeling, respectively …