In-cell structural biology aims at extracting structural information about proteins or nucleic
acids in their native, cellular environment. This emerging field holds great promise and is …

G‐quadruplexes are secondary structures formed in G‐rich sequences in DNA and RNA.
Considerable research over the past three decades has led to in‐depth insight into these …

NMR spectroscopy has been applied to cells and tissues analysis since its beginnings, as
early as 1950. We have attempted to gather here in a didactic fashion the broad diversity of …

Fluorine chemistry has taken a pivotal role in chemical reaction discovery, drug
development, and chemical biology. NMR spectroscopy, arguably the most important …

Although the telomeric sequence has been reported to form various G-quadruplex
topologies in vitro and in Xenopus laevis oocytes, in living human cells, the topology of …

Initial successes in developing small molecule ligands for non-coding RNAs have
underscored their potential as therapeutic targets. More recently, these successes have …

G-quadruplexes (G4s) are noncanonical nucleic acid secondary structures with diverse
topological features and biological roles. Human telomeric (Htelo) overhangs consisting of …

In nucleotide expansion disorders, RNA foci are reportedly associated with
neurodegenerative disease pathogeneses. Characteristically, these RNAs exhibit long poly …

In the present study, we employed a 19F NMR approach to study the association of telomere
RNA and DNA in vitro and in living human cells. We successfully characterized the DNA …

Z-DNA is known to be a left-handed alternative form of DNA and has important biological
roles as well as being related to cancer and other genetic diseases. It is therefore important …