Abstract p53 functions as a transcription factor involved in cell-cycle control, DNA repair,
apoptosis and cellular stress responses. However, besides inducing cell growth arrest and …

MicroRNAs (miRNAs) are a class of short non-coding RNAs that bind mRNAs through partial
base-pair complementarity with their target genes, resulting in post-transcriptional …

Loss of functionality during aging of cells and organisms is caused and accompanied by
altered cell-to-cell communication and signalling. One factor thereby is the chronic …

It is generally considered that Parkinson's disease is induced by specific agents that
degenerate a clearly defined population of dopaminergic neurons. Data commented in this …

A major issue in aging research is how cellular phenomena affect aging at the systemic
level. Emerging evidence suggests that DNA damage response (DDR) signaling is a key …

Oxidative stress has been demonstrated to play a causal role in different vascular diseases,
such as hypertension, diabetic vasculopathy, hypercholesterolemia and atherosclerosis …

Prolonged hypoxia, the event of insufficient oxygen, is known to upregulate tumor
development and growth by promoting the formation of a neoplastic environment. The recent …

Accumulation of misfolded protein aggregates is a hallmark event in many age-related
protein misfolding disorders, including some of the most prevalent and insidious …

Mammalian sirtuins are involved in the control of metabolism and life-span regulation. Here,
we link the mitochondrial sirtuin SIRT4 with cellular senescence, skin aging, and …

Aging is characterized, amongst other features, by a complex process of cellular
senescence involving both innate and adaptive immunity, called immunosenescence and …