The high osmolarity glycerol (HOG) pathway in fungi

H Yaakoub, NS Sanchez, L Ongay-Larios… - Critical Reviews in …, 2022 - Taylor & Francis
While fungi are widely occupying nature, many species are responsible for devastating
mycosis in humans. Such niche diversity explains how quick fungal adaptation is necessary …

The impact of bZIP Atf1ortholog global regulators in fungi

É Leiter, T Emri, K Pákozdi, L Hornok, I Pócsi - Applied Microbiology and …, 2021 - Springer
Regulation of signal transduction pathways is crucial for the maintenance of cellular
homeostasis and organismal development in fungi. Transcription factors are key elements of …

Aspergillus fumigatus mitogen-activated protein kinase MpkA is involved in gliotoxin production and self-protection

P Alves de Castro, C Figueiredo Pinzan… - Nature …, 2024 - nature.com
Aspergillus fumigatus is a saprophytic fungus that can cause a variety of human diseases
known as aspergillosis. Mycotoxin gliotoxin (GT) production is important for its virulence and …

Functional genomic and biochemical analysis reveals pleiotropic effect of Congo red on Aspergillus fumigatus

Z Liu, S Raj, N Van Rhijn, M Fraczek, JP Michel… - MBio, 2021 - Am Soc Microbiol
Inhibition of fungal growth by Congo red (CR) has been putatively associated with specific
binding to β-1, 3-glucans, which blocks cell wall polysaccharide synthesis. In this study, we …

The Aspergillus fumigatus transcription factor RglT is important for gliotoxin biosynthesis and self-protection, and virulence

LNA Ries, L Pardeshi, Z Dong, K Tan… - PLoS …, 2020 - journals.plos.org
Aspergillus fumigatus is an opportunistic fungal pathogen that secretes an array of immune-
modulatory molecules, including secondary metabolites (SMs), which contribute to …

MAPK signaling pathway orchestrates and fine-tunes the pathogenicity of Colletotrichum falcatum

RS Gujjar, R Kumar, SK Goswami, S Srivastava… - Journal of …, 2024 - Elsevier
Colletotrichum falcatum is the causal organism of red rot, the most devastating disease of
sugarcane. Mitogen-activated protein kinase (MAPK) signaling pathway plays pivotal role in …

Loss of Septation Initiation Network (SIN) kinases blocks tissue invasion and unlocks echinocandin cidal activity against Aspergillus fumigatus

ACO Souza, A Martin-Vicente, AV Nywening… - PLoS …, 2021 - journals.plos.org
Although considered effective treatment for many yeast fungi, the therapeutic efficacy of the
echinocandin class of antifungals for invasive aspergillosis (IA) is limited. Recent studies …

Stress tolerance phenotype of industrial yeast: industrial cases, cellular changes, and improvement strategies

X Qiu, J Zhang, J Zhou, Z Fang, Z Zhu, J Li… - Applied microbiology and …, 2019 - Springer
Yeast is widely used in the baking, biocontrol, brewing, and bio manufacturing industries. In
the baking industry alone, around two million tons of yeast are consumed worldwide every …

The Aspergillus fumigatus phosphoproteome reveals roles of high-osmolarity glycerol mitogen-activated protein kinases in promoting cell wall damage and …

EC Mattos, LP Silva, C Valero, PA de Castro… - MBio, 2020 - Am Soc Microbiol
The filamentous fungus Aspergillus fumigatus can cause a distinct set of clinical disorders in
humans. Invasive aspergillosis (IA) is the most common life-threatening fungal disease of …

Light signaling regulates Aspergillus niger biofilm formation by affecting melanin and extracellular polysaccharide biosynthesis

W Sun, Y Yu, J Chen, B Yu, T Chen, H Ying, S Zhou… - Mbio, 2021 - Am Soc Microbiol
Light is an important signal source in nature, which regulates the physiological cycle,
morphogenetic pathways, and secondary metabolites of fungi. As an external pressure on …