Alzheimer's disease (AD) is the leading cause of dementia. The two histopathological
markers of AD are amyloid plaques composed of the amyloid-β (Aβ) peptide, and …

Osteoclasts are bone-resorbing cells that are derived from hematopoietic precursor cells
and require macrophage-colony stimulating factor and receptor activator of nuclear factor-κB …

TREM2 variants have been identified as risk factors for Alzheimer's disease (AD) and other
neurodegenerative diseases (NDDs). Because TREM2 encodes a receptor exclusively …

Genome-wide association studies have identified rare variants of the gene that encodes
triggering receptor expressed on myeloid cells 2 (TREM2)—an immune receptor that is …

Multinucleation is a hallmark of osteoclast maturation. The unique and dynamic
multinucleation process not only increases cell size but causes functional alterations …

The protein triggering receptor expressed on myeloid cells-2 (TREM2) is an
immunomodulatory receptor with a central role in myeloid cell activation and survival. In …

The triggering receptor expressed on myeloid cells 2 (TREM-2) delivers intracellular signals
through the adaptor DAP12 to regulate myeloid cell function both within and outside the …

Macrophage cell fusion and multinucleation are fundamental processes in the formation of
multinucleated giant cells (MGCs) in chronic inflammatory disease and osteoclasts in the …

Monocytes and macrophages are innate immune cells with diverse functions ranging from
phagocytosis of microorganisms to forming a bridge with the adaptive immune system. A …

The activation and fusion of macrophages and of osteoclasts require the adaptor molecule
DNAX-activating protein of 12 kD (DAP12), which contains immunoreceptor tyrosine-based …