Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …

Neurotransmitter receptor systems have been the focus of intensive pharmacological
research for more than 20 years for basic and applied scientific reasons, but only recently …

Postmortem prefrontal cortices (PFC)(Brodmann's areas 10 and 46), temporal cortices
(Brodmann's area 22), hippocampi, caudate nuclei, and cerebella of schizophrenia patients …

During embryonic development of brain laminated structures, the protein Reelin, secreted
into the extracellular matrix of the cortex and hippocampus by Cajal–Retzius (CR) cells …

The relation between changes in brain and plasma concentrations of neurosteroids and the
function and structure of γ-aminobutyric acid type A (GABAA) receptors in the brain during …

Reelin and glutamic acid decarboxylase (GAD) 67 expressed by cortical γ-aminobutyric acid-
ergic interneurons are down-regulated in schizophrenia. Because epidemiological studies …

In the prefrontal cortex of subjects with schizophrenia, markers of the synthesis and re-
uptake of GABA appear to be selectively altered in a subset of interneurons that includes …

Rationale Cortical γ-aminobutyric acid (GABA) ergic neurons contribute to the orchestration
of pyramidal neuron population firing as follows:(1) by releasing GABA on GABA A and …

Over the past several decades, benzodiazepines and the newer non-benzodiazepines have
become the anxiolytic/hypnotics of choice over the more readily abused barbiturates. While …

Abstract Background Repetitive Transcranial Magnetic Stimulation (rTMS) is commonly
administered to Major Depressive Disorder (MDD) patients taking psychotropic medications …