We encounter pathogens on a daily basis and our immune system has evolved to mount an
immune response following an infection. An interesting phenomenon that has evolved in …

Long-term non-progressors (LTNP) were identified after 10–15 years of the epidemic, and
have been the subject of intense investigation ever since. In a small minority of cases …

Human immunodeficiency virus type 1 (HIV-1) controllers maintain viremia at< 2,000 RNA
copies/ml without antiretroviral therapy. Viruses from controllers with chronic infection were …

The mechanisms underlying HIV-1 control by protective HLA class I alleles are not fully
understood and could involve selection of escape mutations in functionally important Gag …

HLA class I polymorphism has a major influence on adult HIV disease progression. An
important mechanism mediating this effect is the impact on viral replicative capacity (VRC) of …

Background A modest change in HIV-1 fitness can have a significant impact on viral
quasispecies evolution and viral pathogenesis, transmission and disease progression. To …

Viremic controllers and elite controllers/suppressors maintain control over HIV-1 replication.
Some studies have suggested that control is a result of infection with a defective viral strain …

Genomic studies involving well‐defined multicenter cohorts of HIV‐1/AIDS covering multiple
populations have led to a greater understanding of the role of host determinants in viral …

ABSTRACT HLA class I-mediated selection of immune escape mutations in functionally
important Gag epitopes may partly explain slower disease progression in HIV-1-infected …

Although laboratory-adapted HIV-1 strains are largely resistant to the human restriction
factor TRIM5α (hTRIM5α), we have recently shown that some viruses carrying capsid (CA) …