Antibody-mediated rejection (AMR) is a recognized cause of allograft dysfunction in lung
transplant recipients. Unlike AMR in other solid-organ transplant recipients, there are no …

Background When the original definition of BOS was formulated in 1993, the working group
had several goals. The group aimed to provide a classification system for airway disease …

Bronchiolitis obliterans syndrome (BOS) is a major complication of lung transplantation that
is associated with poor survival. The International Society for Heart and Lung …

According to the humoral theory of transplantation, antibodies cause allograft rejection.
Publications are cited showing that antibodies:(1) cause hyperacute kidney rejection,(2) …

HLA antibodies have been shown to be associated with late graft loss of organ transplants in
prior studies. Recently they were even shown to appear years BEFORE rejection.(1) An …

One of the earliest controversies in the field of transplantation, after the demonstration by
Brent that the homograft (allograft) reaction was immunologic, was whether grafts are …

Over the last decade, improvements in surgical techniques, lung preservation,
immunosuppression, and management of ischemia–reperfusion injury and infections have …

Bronchiolitis obliterans syndrome (BOS) is the major obstacle to long-term survival after lung
transplantation, in part because its pathogenesis is poorly understood and treatment options …

Background. Recent studies show that almost all patients who have rejected a kidney
transplant had human leukocyte antigen (HLA) antibodies. In this study, we sought to …

Background: Obliterative bronchiolitis remains the major limitation to long-term survival after
lung transplantation. A thorough understanding of the factors that confer high risk of …