In genetic toxicology, risk assessment has traditionally adopted linear dose–responses for
any compound that causes genotoxic effects. Increasing evidence of non-linear dose …

Making research data findable, accessible, interoperable and reusable (FAIR) is typically
hampered by a lack of skills in technical aspects of data management by data generators …

Acrylamide (AA), a human neurotoxicant and rat tumorigen, is produced in starchy foods
when cooked. AA is also an industrial chemical used in polyacrylamide production. A safety …

Genetic toxicology data have traditionally been employed for qualitative, rather than
quantitative evaluations of hazard. As a continuation of our earlier report that analyzed ethyl …

The screen‐and‐bin approach for interpretation of genotoxicity data is predicated on three
false assumptions: that genotoxicants are rare, that genotoxicity dose–response functions do …

Genetic toxicology studies are required for the safety assessment of chemicals. Data from
these studies have historically been interpreted in a qualitative, dichotomous “yes” or “no” …

The potent renal carcinogenicity of ochratoxin A (OTA) in rats, principally in the male, raises
questions about mechanism. Chromatographic evidence of DNA adducts after 32P …

Using the combination of bacterial gene mutation assay and chromosomal aberrations test
in mammalian cells may not detect a small proportion of mammalian specific mutagenic …

Abstract N-Nitrosodiethylamine (NDEA), a well-studied N-nitrosamine, was tested in rats to
compare the dose-response relationship of three genotoxicity endpoints. Mutant/mutation …

The DNA-alkylating metabolite tilimycin is a microbial genotoxin. Intestinal accumulation of
tilimycin in individuals carrying til+ Klebsiella spp. causes apoptotic erosion of the epithelium …