A review of pre-clinical models for Gulf War Illness
ACR Ribeiro, LS Deshpande - Pharmacology & therapeutics, 2021 - Elsevier
Abstract Gulf War Illness (GWI) is a chronic multisymptomatic disorder that afflicts over 1/3rd
of the 1991 GW veterans. It spans multiple bodily systems and presents itself as a syndrome …
of the 1991 GW veterans. It spans multiple bodily systems and presents itself as a syndrome …
Pathophysiological basis and promise of experimental therapies for Gulf War Illness, a chronic neuropsychiatric syndrome in veterans
This article describes the pathophysiology and potential treatments for Gulf War Illness
(GWI), which is a chronic neuropsychiatric illness linked to a combination of chemical …
(GWI), which is a chronic neuropsychiatric illness linked to a combination of chemical …
[HTML][HTML] Deficiency of the CYLD impairs fear memory of mice and disrupts neuronal activity and synaptic transmission in the basolateral amygdala
H Li, D Li, L Yang, C Long - Frontiers in Cellular Neuroscience, 2021 - frontiersin.org
Fear learning and memory are crucial for animal survival. Abnormal fear memory is a
hallmark of many neuropsychiatric disorders. Appropriate neuronal activation and …
hallmark of many neuropsychiatric disorders. Appropriate neuronal activation and …
[HTML][HTML] Pharmacological induction of AMFR increases functional EAAT2 oligomer levels and reduces epileptic seizures in mice
L Sha, G Li, X Zhang, Y Lin, Y Qiu, Y Deng, W Zhu… - JCI insight, 2022 - ncbi.nlm.nih.gov
Dysregulation of excitatory amino acid transporter 2 (EAAT2) contributes to the development
of temporal lobe epilepsy (TLE). Several strategies for increasing total EAAT2 levels have …
of temporal lobe epilepsy (TLE). Several strategies for increasing total EAAT2 levels have …
[HTML][HTML] The β-adrenergic receptor blocker and anti-inflammatory drug propranolol mitigates brain cytokine expression in a long-term model of Gulf War Illness
Aims Growing evidence suggests that Gulf War Illness (GWI) is the result of underlying
neuroimmune dysfunction. For example, previously we found that several GWI-relevant …
neuroimmune dysfunction. For example, previously we found that several GWI-relevant …
Delayed treatment with the immunotherapeutic LNFPIII ameliorates multiple neurological deficits in a pesticide-nerve agent prophylactic mouse model of Gulf War …
JM Carpenter, KA Brown, AN Diaz, RL Dockman… - Neurotoxicology and …, 2021 - Elsevier
Residual effects of the 1990–1991 Gulf War (GW) still plague veterans 30 years later as Gulf
War Illness (GWI). Thought to stem mostly from deployment-related chemical overexposures …
War Illness (GWI). Thought to stem mostly from deployment-related chemical overexposures …
Emerging role of glutamate in the pathophysiology and therapeutics of Gulf War illness
Gulf War illness (GWI) is a chronic and multi-symptomatic disorder affecting veterans who
served in the Gulf War. The commonly reported symptoms in GWI veterans include mood …
served in the Gulf War. The commonly reported symptoms in GWI veterans include mood …
Lacto-N-fucopentaose-III ameliorates acute and persisting hippocampal synaptic plasticity and transmission deficits in a Gulf War Illness mouse model
KA Brown, JM Carpenter, CJ Preston, HD Ludwig… - Life Sciences, 2021 - Elsevier
Aims The present study investigated if treatment with the immunotherapeutic, lacto-N-
fucopentaose-III (LNFPIII), resulted in amelioration of acute and persisting deficits in synaptic …
fucopentaose-III (LNFPIII), resulted in amelioration of acute and persisting deficits in synaptic …
Astrocyte‐selective STAT3 knockdown rescues methamphetamine withdrawal‐disrupted spatial memory in mice via restoring the astrocytic capacity of glutamate …
P Shi, Z Li, T He, N Li, X Xu, P Yu, X Lu, J Nie, D Liu… - Glia, 2021 - Wiley Online Library
Methamphetamine (METH) is a common abused drug. METH‐triggered glutamate (Glu)
levels in dorsal CA1 (dCA1) could partially explain the etiology of METH‐caused abnormal …
levels in dorsal CA1 (dCA1) could partially explain the etiology of METH‐caused abnormal …
Pathological polarizations from microglia to astrocyte contributes to spatial memory deficit in methamphetamine abstinence mice
Y Mai, Z Cheng, Z Wang, T Hu, Y Zhang… - Cerebral …, 2024 - academic.oup.com
Previously, we found that dCA1 A1-like polarization of astrocytes contributes a lot to the
spatial memory deficit in methamphetamine abstinence mice. However, the underlying …
spatial memory deficit in methamphetamine abstinence mice. However, the underlying …