Endometrial cancer is the most common gynaecological tumour in developed countries, and
its incidence is increasing. The most frequently occurring histological subtype is …

In recent years, accumulating evidence has elucidated the role of lysosomes in dynamically
regulating cellular and organismal homeostasis. Lysosomal changes and dysfunction have …

A European consensus conference on endometrial carcinoma was held in 2014 to produce
multi-disciplinary evidence-based guidelines on selected questions. Given the large body of …

Endometrial cancer is the most common gynaecological malignancy in Europe and North
America. Traditional classification of endometrial carcinoma is based either on clinical and …

Endometrial cancer is the sixth most common malignancy among females worldwide with an
estimated incidence of about 288 000 new cases in the year 2008. In developed countries …

The conserved serine/threonine kinase mTOR (the mammalian target of rapamycin), a
downstream effector of the PI3K/AKT pathway, forms two distinct multiprotein complexes …

Advanced and recurrent gynecological cancers are associated with poor prognosis and lack
of effective treatment. The developments of the molecular mechanisms on cancer …

Large efforts dedicated to detect somatic alterations across tumor genomes/exomes are
expected to produce significant improvements in precision cancer medicine. However, high …

Endometrial cancer is the most common gynecologic malignancy in the United States.
Overactivation of the PI3K/AKT/mTOR pathway, a signaling pathway that plays an important …

Endometrial cancer is the most prevalent gynecologic cancer in the United States. Over the
last 10 years, death rates from endometrial cancer have been rising about 1.4% per year …