Osteocytes in bone aging: Advances, challenges, and future perspectives

J Cui, Y Shibata, T Zhu, J Zhou, J Zhang - Ageing research reviews, 2022 - Elsevier
Osteocytes play a critical role in maintaining bone homeostasis and in regulating skeletal
response to hormones and mechanical loading. Substantial evidence have demonstrated …

Skeletal changes during and after spaceflight

L Vico, A Hargens - Nature Reviews Rheumatology, 2018 - nature.com
Abstract Space sojourns are challenging for life. The ability of the human body to adapt to
these extreme conditions has been noted since the beginning of human space travel …

M2 Macrophagy-derived exosomal miRNA-5106 induces bone mesenchymal stem cells towards osteoblastic fate by targeting salt-inducible kinase 2 and 3

Y Xiong, L Chen, C Yan, W Zhou, T Yu, Y Sun… - Journal of …, 2020 - Springer
Background Osteoblast differentiation is a vital process for fracture healing, and exosomes
are nanosized membrane vesicles that can deliver therapeutic drugs easily and safely …

Osteocytes and estrogen deficiency

LM McNamara - Current osteoporosis reports, 2021 - Springer
Abstract Purpose of Review Postmenopausal osteoporosis reduces circulating estrogen
levels, which leads to osteoclast resorption, bone loss, and fracture. This review addresses …

[图书][B] Vertebrate skeletal histology and paleohistology

V de Buffrénil, AJ de Ricqlès, L Zylberberg, K Padian - 2021 - books.google.com
Vertebrate Skeletal Histology and Paleohistology summarizes decades of research into the
biology and biological meaning of hard tissues, in both living and extinct vertebrates. In …

Changes in the osteocyte lacunocanalicular network with aging

LAM Tiede-Lewis, SL Dallas - Bone, 2019 - Elsevier
Osteoporosis is an aging-related disease of reduced bone mass that is particularly prevalent
in post-menopausal women, but also affects the aged male population and is associated …

50 years of scanning electron microscopy of bone—a comprehensive overview of the important discoveries made and insights gained into bone material properties in …

FA Shah, K Ruscsák, A Palmquist - Bone research, 2019 - nature.com
Bone is an architecturally complex system that constantly undergoes structural and
functional optimisation through renewal and repair. The scanning electron microscope …

One-month spaceflight compromises the bone microstructure, tissue-level mechanical properties, osteocyte survival and lacunae volume in mature mice skeletons

M Gerbaix, V Gnyubkin, D Farlay, C Olivier… - Scientific reports, 2017 - nature.com
The weightless environment during spaceflight induces site-specific bone loss. The 30-day
Bion-M1 mission offered a unique opportunity to characterize the skeletal changes after …

Long‐term immobilization in elderly females causes a specific pattern of cortical bone and osteocyte deterioration different from postmenopausal osteoporosis

T Rolvien, P Milovanovic, FN Schmidt… - Journal of Bone and …, 2020 - academic.oup.com
Immobilization as a result of long‐term bed rest can lead to gradual bone loss. Because of
their distribution throughout the bone matrix and remarkable interconnectivity, osteocytes …

Network architecture strongly influences the fluid flow pattern through the lacunocanalicular network in human osteons

AF van Tol, A Roschger, F Repp, J Chen… - … and Modeling in …, 2020 - Springer
A popular hypothesis explains the mechanosensitivity of bone due to osteocytes sensing the
load-induced flow of interstitial fluid squeezed through the lacunocanalicular network (LCN) …