Macrophages are innate immune cells with a dynamic range of reversible activation states
including the classical pro-inflammatory (M1) and alternative anti-inflammatory (M2) states …

The widespread incidence of cardiovascular diseases and associated mortality and
morbidity, along with the advent of powerful computational resources, have fostered an …

Idiopathic pulmonary fibrosis (IPF) is characterised by an important remodelling of lung
parenchyma. Current evidence indicates that the disease is triggered by alveolar epithelium …

microRNAs (miRNAs) are a class of small non-coding RNAs that regulate the expression of
their target mRNAs post transcriptionally. miRNAs are known to regulate not just a gene but …

Now is the time to refocus efforts in urban research and design. A changing climate and
extreme weather events are presenting unique challenges to urban systems around the …

Abstract Ideally, a Systems Toxicology (ST) approach is aimed at by (eco) toxicologists, ie a
multidisciplinary area incorporating classical toxicological concepts with omics technologies …

The endothelium is the single layer of cells lining all blood vessels, and it is a remarkable
cardiovascular control centre. Each endothelial cell has only a small number (on average …

Scientific reductionism has been the basis of disease classification and understanding for
more than a century. However, the reductionist approach of characterizing diseases from a …

Cannabis sativa is a medicinal herb with a diverse range of chemotypes that can exert both
anxiolytic and anxiogenic effects on humans. Medical cannabis patients receiving …

Complexity has radically changed human understanding of the world environment and
continues challenging our best scientific theories. In a rapidly changing research landscape …