Impaired intestinal barrier and tissue bacteria: pathomechanisms for metabolic diseases

L Massier, M Blüher, P Kovacs… - Frontiers in …, 2021 - frontiersin.org
An intact intestinal barrier, representing the interface between inner and outer environments,
is an integral regulator of health. Among several factors, bacteria and their products have …

Sodium butyrate protects mice from the development of the early signs of non-alcoholic fatty liver disease: role of melatonin and lipid peroxidation

CJ Jin, AJ Engstler, C Sellmann… - British Journal of …, 2016 - cambridge.org
Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases
worldwide with universally accepted treatments still lacking. Oral supplementation of sodium …

From NAFLD to MAFLD: aligning translational in vitro research to clinical insights

A Gatzios, M Rombaut, K Buyl, J De Kock… - Biomedicines, 2022 - mdpi.com
Although most same-stage non-alcoholic fatty liver disease (NAFLD) patients exhibit similar
histologic sequelae, the underlying mechanisms appear to be highly heterogeneous …

Protective effects of lactic acid bacteria against TLR4 induced inflammatory response in hepatoma HepG2 cells through modulation of toll-like receptor negative …

P Kanmani, H Kim - Frontiers in immunology, 2018 - frontiersin.org
The beneficial effects of probiotics in several liver diseases have been investigated in both
animal and clinical models; however, the precise mechanisms responsible for their effects …

Pro-and anti-inflammatory responses of common carp Cyprinus carpio head kidney leukocytes to E. coli LPS as modified by different dietary plant oils

TM Nguyen, SNM Mandiki, JMAJ Salomon… - Developmental & …, 2021 - Elsevier
Dietary lipids could modify fatty acid (FA) composition in fish tissues. Long chain
polyunsaturated fatty acids (LC-PUFAs) such as arachidonic acid (ARA), eicosapentaneoic …

Free fatty acids promote the development of prostate cancer by upregulating peroxisome proliferator-activated receptor gamma

X Ha, J Wang, K Chen, Y Deng, X Zhang… - Cancer management …, 2020 - Taylor & Francis
Introduction As one of the most common forms of cancer that threatens men's health,
prostate cancer (PCa) is under a trend of increasing morbidity and mortality in most …

Immunobiotics beneficially modulate TLR4 signaling triggered by lipopolysaccharide and reduce hepatic steatosis in vitro

P Kanmani, AZ Ansari, J Villena… - Journal of immunology …, 2019 - Wiley Online Library
Hepatic inflammation and injury may result from the translocation of pathological bacteria
and their proinflammatory mediators. Probiotics attenuate hepatic diseases related to …

Metabolomic analysis of a selective ABCA1 inducer in obesogenic challenge provides a rationale for therapeutic development

CT Lewandowski, MW Khan, M BenAissa… - …, 2021 - thelancet.com
Background Therapeutic agents with novel mechanisms of action are needed to combat the
growing epidemic of type 2 diabetes (T2D) and related metabolic syndromes. Liver X …

Oleander attenuates hepatic inflammation in a TLR4-independent manner and by favorable modulation of hepatocellular global metabolome that supports …

P Dey, N Tewari, S Dutta, RA Newman… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Nerium oleander is used to treat liver-associated chronic
metabolic diseases in traditional medicinal systems across the globe. The hepatoprotective …

Vitamin D3 supplementation of a high fat high sugar diet ameliorates prediabetic phenotype in female LDLR−/− and LDLR+/+ mice

R Kheder, J Hobkirk, Z Saeed, J Janus… - Immunity …, 2017 - Wiley Online Library
Introduction Fatty liver disease is prevalent in populations with high caloric intake.
Nutritherapeutic approaches are being considered, such as supplementary Vitamin D3, to …