Three-dimensional in vitro culture models in oncology research
Cancer is a multifactorial disease that is responsible for 10 million deaths per year. The intra-
and inter-heterogeneity of malignant tumors make it difficult to develop single targeted …
and inter-heterogeneity of malignant tumors make it difficult to develop single targeted …
Three-dimensional spheroids as in vitro preclinical models for cancer research
Most cancer biologists still rely on conventional two-dimensional (2D) monolayer culture
techniques to test in vitro anti-tumor drugs prior to in vivo testing. However, the vast majority …
techniques to test in vitro anti-tumor drugs prior to in vivo testing. However, the vast majority …
3D cell culture models as recapitulators of the tumor microenvironment for the screening of anti-cancer drugs
Simple Summary Three-dimensional (3D) cell culture models have been proposed as
alternatives for initial drug screening to increase drug development efficiency. In addition to …
alternatives for initial drug screening to increase drug development efficiency. In addition to …
Halfway between 2D and animal models: are 3D cultures the ideal tool to study cancer-microenvironment interactions?
An area that has come to be of tremendous interest in tumor research in the last decade is
the role of the microenvironment in the biology of neoplastic diseases. The tumor …
the role of the microenvironment in the biology of neoplastic diseases. The tumor …
Three-dimensional culture systems in cancer research: Focus on tumor spheroid model
S Nath, GR Devi - Pharmacology & therapeutics, 2016 - Elsevier
Cancer cells propagated in three-dimensional (3D) culture systems exhibit physiologically
relevant cell–cell and cell–matrix interactions, gene expression and signaling pathway …
relevant cell–cell and cell–matrix interactions, gene expression and signaling pathway …
3D tumor spheroid models for in vitro therapeutic screening: a systematic approach to enhance the biological relevance of data obtained
The potential of a spheroid tumor model composed of cells in different proliferative and
metabolic states for the development of new anticancer strategies has been amply …
metabolic states for the development of new anticancer strategies has been amply …
Cancer spheroids and organoids as novel tools for research and therapy: state of the art and challenges to guide precision medicine
S El Harane, B Zidi, N El Harane, KH Krause, T Matthes… - Cells, 2023 - mdpi.com
Spheroids and organoids are important novel players in medical and life science research.
They are gradually replacing two-dimensional (2D) cell cultures. Indeed, three-dimensional …
They are gradually replacing two-dimensional (2D) cell cultures. Indeed, three-dimensional …
3D bioprinted in vitro metastatic models via reconstruction of tumor microenvironments
The development of 3D in vitro models capable of recapitulating native tumor
microenvironments could improve the translatability of potential anticancer drugs and …
microenvironments could improve the translatability of potential anticancer drugs and …
Modeling tumor phenotypes in vitro with three-dimensional bioprinting
EM Langer, BL Allen-Petersen, SM King… - Cell reports, 2019 - cell.com
The tumor microenvironment plays a critical role in tumor growth, progression, and
therapeutic resistance, but interrogating the role of specific tumor-stromal interactions on …
therapeutic resistance, but interrogating the role of specific tumor-stromal interactions on …
Principles of the Kenzan Method for Robotic Cell Spheroid-Based Three-Dimensional Bioprinting
NI Moldovan, N Hibino, K Nakayama - Tissue Engineering Part B …, 2017 - liebertpub.com
Bioprinting is a technology with the prospect to change the way many diseases are treated,
by replacing the damaged tissues with live de novo created biosimilar constructs. However …
by replacing the damaged tissues with live de novo created biosimilar constructs. However …