o-Silylaryl Triflates: A Journey of Kobayashi Aryne Precursors

J Shi, L Li, Y Li - Chemical Reviews, 2021 - ACS Publications
Arynes are among the most active organic intermediates and have found numerous
applications in expeditious preparation of substituted arenes. In the past 20 years, chemists …

Transition-metal-free coupling reactions

CL Sun, ZJ Shi - Chemical reviews, 2014 - ACS Publications
Transition-metal-catalyzed reactions have been studied since the very beginning of the past
century and represent a great success in organic chemistry, along with the birth and growth …

Coumarins as anticancer agents: A review on synthetic strategies, mechanism of action and SAR studies

A Thakur, R Singla, V Jaitak - European journal of medicinal chemistry, 2015 - Elsevier
Coumarins are fused benzene and pyrone ring systems which prompt biological
investigation to assess their potential therapeutic significance. It possesses immeasurable …

Beyond a solvent: triple roles of dimethylformamide in organic chemistry

MM Heravi, M Ghavidel, L Mohammadkhani - RSC advances, 2018 - pubs.rsc.org
N, N-Dimethylformamide (DMF) is frequently used as an aprotic solvent in chemical
transformations in laboratories of academia as well as in those of chemical industry. In the …

Recent advances in transition-metal-free carbon–carbon and carbon–heteroatom bond-forming reactions using arynes

A Bhunia, SR Yetra, AT Biju - Chemical Society Reviews, 2012 - pubs.rsc.org
This tutorial review is aimed at highlighting recent developments in transition-metal-free
carbon–carbon and carbon–heteroatom bond-forming reactions utilizing a versatile class of …

Use of benzynes for the synthesis of heterocycles

AV Dubrovskiy, NA Markina, RC Larock - Organic & Biomolecular …, 2013 - pubs.rsc.org
About two decades after Kobayashi's discovery in 1983 of a very mild way of generating
highly reactive aryne intermediates, the synthetic community embraced o-(trimethylsilyl) aryl …

N,N‐Dimethylformamide: A Multipurpose Building Block

S Ding, N Jiao - Angewandte Chemie International Edition, 2012 - Wiley Online Library
Often used as a common solvent for chemical reations and utilized widely in industry as a
reagent, N, N‐dimethylformamide (DMF) has played an important role in organic synthesis …

ortho-Quinone methide (o-QM): a highly reactive, ephemeral and versatile intermediate in organic synthesis

MS Singh, A Nagaraju, N Anand, S Chowdhury - RSC advances, 2014 - pubs.rsc.org
Since its first observation in 1907, ortho-quinone methide (o-QM) has occupied a strategic
place within the framework of reactive intermediates in organic synthesis. In recent years, o …

Ketenes and other cumulenes as reactive intermediates

AD Allen, TT Tidwell - Chemical Reviews, 2013 - ACS Publications
Reactive intermediates as recognized chemical entities date back for over a century, and
among the earliest examples were simple free radicals, as identified in 1879, when it was …

Visible-light initiated oxidative cyclization of phenyl propiolates with sulfinic acids to coumarin derivatives under metal-free conditions

W Yang, S Yang, P Li, L Wang - Chemical Communications, 2015 - pubs.rsc.org
A visible-light initiated oxidative cyclization of phenyl propiolates with sulfinic acids has been
developed. The arylsulfonylation of alkynes was performed at room temperature under metal …