Depression is a major contributor to the global burden of disease and disability, yet it is
poorly understood. Here we review data supporting a novel theoretical model for the biology …

Experience and environment can critically influence the risk and progression of
neurodegenerative disorders. Epigenetic mechanisms, such as miRNA expression, DNA …

BACKGROUND: Social stress leads to oxidative stress in the central nervous system,
contributing to the development of mental disorders. Loss of parvalbumin in interneurons is …

Evidence that gene× environment interactions can reflect differential sensitivity to the
environmental context, rather than risk or resilience, is increasing. To test this model, we …

The over-expressed colonic brain-derived neurotrophic factor (BDNF) has been reported to
be associated with abdominal pain in patients with irritable bowel syndrome (IBS). However …

Prenatal stress causes predisposition to cognitive and emotional disturbances and is a risk
factor towards the development of neuropsychiatric conditions like depression, bipolar …

Baicalein (BA), a plant-derived active flavonoid present in the root of Scutellaria baicalensis,
has been widely used for the treatment of stress-related neuropsychiatric disorders including …

Chronic mild stress (CMS) is suggested to develop dysregulation of the limbic-hypothalamic-
pituitary-adrenal (LHPA) stress circuit. Icariin, a major constituent of flavonoids isolated from …

Perfluorooctane sulfonate (PFOS) is a member of the anthropogenic class of perfluorinated
alkyl acids (PFAAs) and one of the most frequently detected PFAAs in water, humans …

Background: Rats subjected to maternal separation display behavioral alterations (eg
increased immobility in the forced swim test) and molecular changes (eg in growth factors …