Cellular distribution and functions of P2 receptor subtypes in different systems
G Burnstock, GE Knight - Int Rev Cytol, 2004 - books.google.com
In 1929 Drury and Szent-Györgyi published a seminal paper describing the potent actions of
adenine compounds. Some decades later, adenosine 5'-triphosphate (ATP) was proposed …
adenine compounds. Some decades later, adenosine 5'-triphosphate (ATP) was proposed …
Pathophysiology and therapeutic potential of purinergic signaling
G Burnstock - Pharmacological reviews, 2006 - ASPET
The concept of a purinergic signaling system, using purine nucleotides and nucleosides as
extracellular messengers, was first proposed over 30 years ago. After a brief introduction …
extracellular messengers, was first proposed over 30 years ago. After a brief introduction …
[HTML][HTML] Molecular and functional properties of P2X receptors—recent progress and persisting challenges
K Kaczmarek-Hájek, É Lörinczi, R Hausmann… - Purinergic …, 2012 - Springer
Abstract ATP-gated P2X receptors are trimeric ion channels that assemble as homo-or
heteromers from seven cloned subunits. Transcripts and/or proteins of P2X subunits have …
heteromers from seven cloned subunits. Transcripts and/or proteins of P2X subunits have …
Contribution of calcium ions to P2X channel responses
TM Egan, BS Khakh - Journal of Neuroscience, 2004 - Soc Neuroscience
Ca2+ entry through transmitter-gated cation channels, including ATP-gated P2X channels,
contributes to an array of physiological processes in excitable and non-excitable cells, but …
contributes to an array of physiological processes in excitable and non-excitable cells, but …
P2X receptors in health and disease
G Burnstock, C Kennedy - Advances in pharmacology, 2011 - Elsevier
Seven P2X receptor subunits have been cloned which form functional homo-and
heterotrimers. These are cation-selective channels, equally permeable to Na+ and K+ and …
heterotrimers. These are cation-selective channels, equally permeable to Na+ and K+ and …
[HTML][HTML] Brain endothelial cell TRPA1 channels initiate neurovascular coupling
Cerebral blood flow is dynamically regulated by neurovascular coupling to meet the
dynamic metabolic demands of the brain. We hypothesized that TRPA1 channels in capillary …
dynamic metabolic demands of the brain. We hypothesized that TRPA1 channels in capillary …
[HTML][HTML] Intercellular calcium signaling induced by ATP potentiates macrophage phagocytosis
Extracellular ATP is a signaling molecule exploited by the immune cells for both autocrine
regulation and paracrine communication. By performing live calcium imaging experiments …
regulation and paracrine communication. By performing live calcium imaging experiments …
Purinergic signaling in the airways
G Burnstock, I Brouns, D Adriaensen… - Pharmacological …, 2012 - ASPET
Evidence for a significant role and impact of purinergic signaling in normal and diseased
airways is now beyond dispute. The present review intends to provide the current state of …
airways is now beyond dispute. The present review intends to provide the current state of …
[HTML][HTML] Nasal irrigation: from empiricism to evidence-based medicine. A review
PL Bastier, A Lechot, L Bordenave, M Durand… - European annals of …, 2015 - Elsevier
Nasal irrigation plays a non-negligible role in the treatment of numerous sinonasal
pathologies and postoperative care. There is, however, a wide variety of protocols. The …
pathologies and postoperative care. There is, however, a wide variety of protocols. The …
[HTML][HTML] Physiological Regulation of ATP Release at the Apical Surface of Human Airway Epithelia*♦
SF Okada, RA Nicholas, SM Kreda… - Journal of Biological …, 2006 - ASBMB
Extracellular ATP and its metabolite adenosine regulate mucociliary clearance in airway
epithelia. Little has been known, however, regarding the actual ATP and adenosine …
epithelia. Little has been known, however, regarding the actual ATP and adenosine …