In 1929 Drury and Szent-Györgyi published a seminal paper describing the potent actions of
adenine compounds. Some decades later, adenosine 5'-triphosphate (ATP) was proposed …

The concept of a purinergic signaling system, using purine nucleotides and nucleosides as
extracellular messengers, was first proposed over 30 years ago. After a brief introduction …

Abstract ATP-gated P2X receptors are trimeric ion channels that assemble as homo-or
heteromers from seven cloned subunits. Transcripts and/or proteins of P2X subunits have …

Ca2+ entry through transmitter-gated cation channels, including ATP-gated P2X channels,
contributes to an array of physiological processes in excitable and non-excitable cells, but …

Seven P2X receptor subunits have been cloned which form functional homo-and
heterotrimers. These are cation-selective channels, equally permeable to Na+ and K+ and …

Cerebral blood flow is dynamically regulated by neurovascular coupling to meet the
dynamic metabolic demands of the brain. We hypothesized that TRPA1 channels in capillary …

Extracellular ATP is a signaling molecule exploited by the immune cells for both autocrine
regulation and paracrine communication. By performing live calcium imaging experiments …

Evidence for a significant role and impact of purinergic signaling in normal and diseased
airways is now beyond dispute. The present review intends to provide the current state of …

Nasal irrigation plays a non-negligible role in the treatment of numerous sinonasal
pathologies and postoperative care. There is, however, a wide variety of protocols. The …

Extracellular ATP and its metabolite adenosine regulate mucociliary clearance in airway
epithelia. Little has been known, however, regarding the actual ATP and adenosine …