Emerging role of nanosuspensions in drug delivery systems
Rapid advancement in drug discovery process is leading to a number of potential new drug
candidates having excellent drug efficacy but limited aqueous solubility. By virtue of the …
candidates having excellent drug efficacy but limited aqueous solubility. By virtue of the …
Untangling mucosal drug delivery: engineering, designing, and testing nanoparticles to overcome the mucus barrier
J Watchorn, AJ Clasky, G Prakash… - ACS Biomaterials …, 2022 - ACS Publications
Mucus is a complex viscoelastic gel and acts as a barrier covering much of the soft tissue in
the human body. High vascularization and accessibility have motivated drug delivery to …
the human body. High vascularization and accessibility have motivated drug delivery to …
Avoiding a sticky situation: bypassing the mucus barrier for improved local drug delivery
The efficacy of drugs administered by traditional routes is limited by numerous biological
barriers that preclude reaching the intended site of action. Further, full body systemic …
barriers that preclude reaching the intended site of action. Further, full body systemic …
[HTML][HTML] Delivery technologies for women's health applications
The treatment of women's health-related conditions, including reproductive tract and
pregnancy disorders, faces distinct challenges and microenvironments, such as the vaginal …
pregnancy disorders, faces distinct challenges and microenvironments, such as the vaginal …
In vitro and ex vivo models for evaluating vaginal drug delivery systems
RL Shapiro, K DeLong, F Zulfiqar, D Carter… - Advanced drug delivery …, 2022 - Elsevier
Vaginal drug delivery systems are often preferred for treating a variety of diseases and
conditions of the female reproductive tract (FRT), as delivery can be more targeted with less …
conditions of the female reproductive tract (FRT), as delivery can be more targeted with less …
Next generation strategies for preventing preterm birth
Preterm birth (PTB) is defined as delivery before 37 weeks of gestation. Globally, 15 million
infants are born prematurely, putting these children at an increased risk of mortality and …
infants are born prematurely, putting these children at an increased risk of mortality and …
[HTML][HTML] Landscape of preterm birth therapeutics and a path forward
BS Coler, O Shynlova, A Boros-Rausch, S Lye… - Journal of Clinical …, 2021 - mdpi.com
Preterm birth (PTB) remains the leading cause of infant morbidity and mortality. Despite 50
years of research, therapeutic options are limited and many lack clear efficacy. Tocolytic …
years of research, therapeutic options are limited and many lack clear efficacy. Tocolytic …
Enhanced drug delivery to the reproductive tract using nanomedicine reveals therapeutic options for prevention of preterm birth
HC Zierden, JI Ortiz, K DeLong, J Yu, G Li… - Science translational …, 2021 - science.org
Inflammation contributes to nearly 4 million global premature births annually. Here, we used
a mouse model of intrauterine inflammation to test clinically used formulations, as well as …
a mouse model of intrauterine inflammation to test clinically used formulations, as well as …
Development of nintedanib nanosuspension for inhaled treatment of experimental silicosis
LH Andrade da Silva, JB Vieira… - Bioengineering & …, 2023 - Wiley Online Library
Silicosis is an irreversible and progressive fibrotic lung disease caused by massive
inhalation of crystalline silica dust at workplaces, affecting millions of industrial workers …
inhalation of crystalline silica dust at workplaces, affecting millions of industrial workers …
Women-specific routes of administration for drugs: A critical overview
The woman's body presents a number of unique anatomical features that can constitute
valuable routes for the administration of drugs, either for local or systemic action. These are …
valuable routes for the administration of drugs, either for local or systemic action. These are …