Emerging role of nanosuspensions in drug delivery systems

S Jacob, AB Nair, J Shah - Biomaterials research, 2020 - spj.science.org
Rapid advancement in drug discovery process is leading to a number of potential new drug
candidates having excellent drug efficacy but limited aqueous solubility. By virtue of the …

Untangling mucosal drug delivery: engineering, designing, and testing nanoparticles to overcome the mucus barrier

J Watchorn, AJ Clasky, G Prakash… - ACS Biomaterials …, 2022 - ACS Publications
Mucus is a complex viscoelastic gel and acts as a barrier covering much of the soft tissue in
the human body. High vascularization and accessibility have motivated drug delivery to …

Avoiding a sticky situation: bypassing the mucus barrier for improved local drug delivery

HC Zierden, A Josyula, RL Shapiro, HT Hsueh… - Trends in molecular …, 2021 - cell.com
The efficacy of drugs administered by traditional routes is limited by numerous biological
barriers that preclude reaching the intended site of action. Further, full body systemic …

[HTML][HTML] Delivery technologies for women's health applications

KL Swingle, AS Ricciardi, WH Peranteau… - Nature Reviews …, 2023 - nature.com
The treatment of women's health-related conditions, including reproductive tract and
pregnancy disorders, faces distinct challenges and microenvironments, such as the vaginal …

In vitro and ex vivo models for evaluating vaginal drug delivery systems

RL Shapiro, K DeLong, F Zulfiqar, D Carter… - Advanced drug delivery …, 2022 - Elsevier
Vaginal drug delivery systems are often preferred for treating a variety of diseases and
conditions of the female reproductive tract (FRT), as delivery can be more targeted with less …

Next generation strategies for preventing preterm birth

HC Zierden, RL Shapiro, K DeLong, DM Carter… - Advanced drug delivery …, 2021 - Elsevier
Preterm birth (PTB) is defined as delivery before 37 weeks of gestation. Globally, 15 million
infants are born prematurely, putting these children at an increased risk of mortality and …

[HTML][HTML] Landscape of preterm birth therapeutics and a path forward

BS Coler, O Shynlova, A Boros-Rausch, S Lye… - Journal of Clinical …, 2021 - mdpi.com
Preterm birth (PTB) remains the leading cause of infant morbidity and mortality. Despite 50
years of research, therapeutic options are limited and many lack clear efficacy. Tocolytic …

Enhanced drug delivery to the reproductive tract using nanomedicine reveals therapeutic options for prevention of preterm birth

HC Zierden, JI Ortiz, K DeLong, J Yu, G Li… - Science translational …, 2021 - science.org
Inflammation contributes to nearly 4 million global premature births annually. Here, we used
a mouse model of intrauterine inflammation to test clinically used formulations, as well as …

Development of nintedanib nanosuspension for inhaled treatment of experimental silicosis

LH Andrade da Silva, JB Vieira… - Bioengineering & …, 2023 - Wiley Online Library
Silicosis is an irreversible and progressive fibrotic lung disease caused by massive
inhalation of crystalline silica dust at workplaces, affecting millions of industrial workers …

Women-specific routes of administration for drugs: A critical overview

J das Neves, F Notario-Perez, B Sarmento - Advanced Drug Delivery …, 2021 - Elsevier
The woman's body presents a number of unique anatomical features that can constitute
valuable routes for the administration of drugs, either for local or systemic action. These are …