Genetic models of human and mouse dendritic cell development and function
Dendritic cells (DCs) develop in the bone marrow from haematopoietic progenitors that have
numerous shared characteristics between mice and humans. Human counterparts of mouse …
numerous shared characteristics between mice and humans. Human counterparts of mouse …
Human dendritic cell subsets: an update
Dendritic cells (DC) are a class of bone‐marrow‐derived cells arising from lympho‐myeloid
haematopoiesis that form an essential interface between the innate sensing of pathogens …
haematopoiesis that form an essential interface between the innate sensing of pathogens …
Complex genetic signatures in immune cells underlie autoimmunity and inform therapy
We report on the influence of~ 22 million variants on 731 immune cell traits in a cohort of
3,757 Sardinians. We detected 122 significant (P< 1.28× 10− 11) independent association …
3,757 Sardinians. We detected 122 significant (P< 1.28× 10− 11) independent association …
Dendritic cell subsets and locations
S Balan, M Saxena, N Bhardwaj - International review of cell and molecular …, 2019 - Elsevier
Dendritic cells (DCs) are a unique class of immune cells that act as a bridge between innate
and adaptive immunity. The discovery of DCs by Cohen and Steinman in 1973 laid the …
and adaptive immunity. The discovery of DCs by Cohen and Steinman in 1973 laid the …
Differential IRF8 transcription factor requirement defines two pathways of dendritic cell development in humans
The formation of mammalian dendritic cells (DCs) is controlled by multiple hematopoietic
transcription factors, including IRF8. Loss of IRF8 exerts a differential effect on DC subsets …
transcription factors, including IRF8. Loss of IRF8 exerts a differential effect on DC subsets …
Transcriptional networks driving dendritic cell differentiation and function
Dendritic cells (DCs) are the sentinels of the immune system, sensing a diverse array of
pathogens to stimulate a robust and appropriate immune response. To initiate responses to …
pathogens to stimulate a robust and appropriate immune response. To initiate responses to …
Inborn errors of human IKAROS: LOF and GOF variants associated with primary immunodeficiency
HS Kuehn, B Boast… - Clinical and Experimental …, 2023 - academic.oup.com
IKAROS/IKZF1 plays a pivotal role in lymphocyte differentiation and development. Germline
mutations in IKZF1, which have been shown to be associated with primary …
mutations in IKZF1, which have been shown to be associated with primary …
Blastic plasmacytoid dendritic cell neoplasm: state of the art and prospects
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an extremely rare tumour, which
usually affects elderly males and presents in the skin with frequent involvement of the bone …
usually affects elderly males and presents in the skin with frequent involvement of the bone …
Genomic signatures reveal DNA damage response deficiency in colorectal cancer brain metastases
J Sun, C Wang, Y Zhang, L Xu, W Fang, Y Zhu… - Nature …, 2019 - nature.com
Brain metastases (BM) of colorectal cancer (CRC) are rare but lethal, and an understanding
of their genomic landscape is lacking. We conduct an analysis of whole-exome sequencing …
of their genomic landscape is lacking. We conduct an analysis of whole-exome sequencing …
Biology and prognostic impact of clonal plasmacytoid dendritic cells in chronic myelomonocytic leukemia
N Lucas, M Duchmann, P Rameau, F Noël, P Michea… - Leukemia, 2019 - nature.com
Islands of CD123high cells have been commonly described in the bone marrow of patients
with chronic myelomonocytic leukemia (CMML). Using a multiparameter flow cytometry …
with chronic myelomonocytic leukemia (CMML). Using a multiparameter flow cytometry …