Proteins are regulated by an incredible array of posttranslational modifications (PTMs).
Methylation of lysine residues on histone proteins is a PTM with well-established roles in …

The PR/SET domain family (PRDM) comprise a family of genes whose protein products
share a conserved N-terminal PR [PRDI-BF1 (positive regulatory domain I-binding factor 1) …

Abstract Programmed death receptor-1 (PD-1) blockade have achieved some efficacy but
only in a fraction of patients with hepatocellular carcinoma (HCC). Programmed cell death 1 …

The PRDM family of proteins share a unique structure, with an N-terminal PR domain, which
has a potential methyltransferase activity, followed by a distinct number of zinc fingers at the …

The PRDM [PRDI-BFI (positive regulatory domain I-binding factor 1) and RIZ1
(retinoblastoma protein-interacting zinc finger gene 1) homologous domain containing] …

Given the frequent and largely incurable occurrence of multiple myeloma, identification of
germline genetic mutations that predispose cells to multiple myeloma may provide insight …

Background To investigate the biological relationship, mechanism between perilipin2 and
the occurrence, advancement of gastric carcinoma, and explore the mechanism of lipid …

Motivation Advances in omics technologies have revolutionized cancer research by
producing massive datasets. Common approaches to deciphering these complex data are …

Hepatocellular carcinoma (HCC) is a major leading cause of cancer mortality worldwide.
PRDI‐BF1 and RIZ homology domain containing 8 (PRDM8) is a key regulator in neural …

MYC represents a transcription factor with oncogenic potential converting multiple cellular
signals into a broad transcriptional response, thereby controlling the expression of …