Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying
development, disease, and regeneration. As organoid research expands, the need for clear …

Cardiovascular disease is the most common cause of death in the world. In severe cases,
replacement or revascularization using vascular grafts are the treatment options. While …

Preventing SARS-CoV-2 infection by modulating viral host receptors, such as angiotensin-
converting enzyme 2 (ACE2), could represent a new chemoprophylactic approach for …

Drug-induced liver injury (DILI) is a patient-specific, temporal, multifactorial
pathophysiological process that cannot yet be recapitulated in a single in vitro model …

Organoid technology holds great promise for regenerative medicine but has not yet been
applied to humans. We address this challenge using cholangiocyte organoids in the context …

Background and Aims Organoids provide a powerful system to study epithelia in vitro.
Recently, this approach was applied successfully to the biliary tree, a series of ductular …

Abstract Background and Aims Biliary atresia is a severe inflammatory and fibrosing
cholangiopathy of neonates of unknown etiology. The onset of cholestasis at birth implies a …

Human cholangiocyte organoids show great promise for regenerative therapies and in vitro
modeling of bile duct development and diseases. However, the cystic organoids lack the …

We are entering an era of medicine where increasingly sophisticated data will be obtained
from patients to determine proper diagnosis, predict outcomes and direct therapies. We …

The liver is a very complex organ that ensures numerous functions; it is thus susceptible to
multiple types of damage and dysfunction. Since 1983, orthotopic liver transplantation (OLT) …