Abstract Methyl-Cobalamin (Cbl) derives from dietary vitamin B12 and acts as a cofactor of
methionine synthase (MS) in mammals. MS encoded by MTR catalyzes the remethylation of …

Sirtuin1 (Sirt1) has a NAD (+) binding domain and modulates the acetylation status of
peroxisome proliferator-activated receptor-γ coactivator-1α (PGC1α) and Fork Head Box O1 …

The pathomechanisms that associate a deficit in folate and/or vitamin B12 and the
subsequent hyperhomocysteinemia with pathological brain ageing are unclear. We …

Methionine-dependency is a common feature of cancer cells, which cannot proliferate
without constant inputs of exogenous methionine even in the presence of its precursor …

The molecular mechanisms that underlie the neurological manifestations of patients with
inherited diseases of vitamin B12 (cobalamin) metabolism remain to date obscure. We …

Background MTR gene encodes the cytoplasmic enzyme methionine synthase, which plays
a pivotal role in the methionine cycle of one-carbon metabolism. This cycle holds a …

Folic acid (FA) is often consumed as a food supplement and can be found in fortified staple
foods in various western countries. Even though FA supplementation during pregnancy is …

Folate is an important B vitamin required for methylation reactions, nucleotide and
neurotransmitter synthesis, and maintenance of homocysteine at nontoxic levels. Its …

Aims Estrogens play pivotal roles in hippocampal synaptic plasticity through nuclear
receptors (nER s; including ER α and ER β) and the membrane receptor (mER; also called …

Deficiencies in methyl donors, folate, and vitamin B12 are known to lead to brain function
defects. Fetal development is the most studied but data are also available for such an impact …