The error rate displayed during template copying to produce viral RNA progeny is a
biologically relevant parameter of the replication complexes of viruses. It has consequences …

In order to survive and propagate, RNA viruses must achieve a balance between the
capacity for adaptation to new environmental conditions or host cells with the need to …

The replication/transcription complex of severe acute respiratory syndrome coronavirus is
composed of at least 16 nonstructural proteins (nsp1–16) encoded by the ORF-1a/1b. This …

The in vitro fidelity of the virion-associated RNA polymerase of vesicular stomatitis virus was
quantitated for a single conserved viral RNA site and the usual high in vitro base …

Replication fidelity of RNA virus genomes is constrained by the opposing necessities of
generating sufficient diversity for adaptation and maintaining genetic stability, but it is …

This chapter discusses the high mutation frequencies and rapid evolution potential of RNA
viruses. The concepts discussed are applicable to all “ordinary” RNA viruses (riboviruses) …

ABSTRACT T-705 (favipiravir; 6-fluoro-3-hydroxy-2-pyrazinecarboxamide) selectively and
strongly inhibits replication of the influenza virus in vitro and in vivo. T-705 has been shown …

A number of virologic and environmental factors are involved in the emergence and re-
emergence of viral disease. Viruses do not conservatively occupy a single and permanent …

Ribonucleoprotein (RNP) cores of influenza virus A/PR/8/34 were dissociated into RNA
polymerase (PB1-PB2-PA complex)-associated genome RNA and nuclear protein (NP) …

In addition to polynucleotide polymerization, DNA polymerases and bacterial RNA
polymerase can also remove nucleotides from the growing end of nucleic acid chains. For …