Applying an evolutionary mismatch framework to understand disease susceptibility

AJ Lea, AG Clark, AW Dahl, O Devinsky, AR Garcia… - PLoS …, 2023 - journals.plos.org
Noncommunicable diseases (NCDs) are on the rise worldwide. Obesity, cardiovascular
disease, and type 2 diabetes are among a long list of “lifestyle” diseases that were rare …

Epidemiological overview of major depressive disorder in Scandinavia using nationwide registers

JA Pasman, JJ Meijsen, M Haram… - The Lancet Regional …, 2023 - thelancet.com
Background Major depressive disorder (MDD) is a common psychiatric disorder associated
with a high disease burden. This study gives a comprehensive overview of the prevalence …

Data Resource Profile: Nationwide registry data for high-throughput epidemiology and machine learning (FinRegistry)

E Viippola, S Kuitunen… - International Journal …, 2023 - academic.oup.com
• FinRegistry is a curated, nationwide, register-based data resource for developing statistical
and machine learning models, performing high-throughput epidemiological analyses and …

Child Mental Health, Family Circumstance, and Long-Term Success: The Effect of Household Income

R Akee, W Copeland, E Simeonova - Journal of Human Resources, 2024 - jhr.uwpress.org
We use data from a long-running experiment in which American Indian households received
income transfers from a casino, while other households did not. Using a difference-in …

The relationship between genotype-and phenotype-based estimates of genetic liability to human psychiatric disorders, in practice and in theory

MD Krebs, V Appadurai, KLG Hellberg, H Ohlsson… - medRxiv, 2023 - medrxiv.org
Genetics as a science has roots in studying phenotypes of relatives, but molecular
approaches facilitate direct measurements of genomic variation within individuals …

Quantifying the relative importance of genetics and environment on the comorbidity between mental and cardiometabolic disorders using 17 million Scandinavians

J Meijsen, K Hu, MD Krebs, G Athanasiadis… - Nature …, 2024 - nature.com
Mental disorders are leading causes of disability and premature death worldwide, partly due
to high comorbidity with cardiometabolic disorders. Reasons for this comorbidity are still …

Diverse environmental perturbations reveal the evolution and context-dependency of genetic effects on gene expression levels

AJ Lea, J Peng, JF Ayroles - Genome Research, 2022 - genome.cshlp.org
There is increasing appreciation that, in addition to being shaped by an individual's
genotype and environment, most complex traits are also determined by poorly understood …

Uncovering the heritable components of multimorbidities and disease trajectories using a nationwide cohort

D Westergaard, FH Jørgensen, J Waaben… - Nature …, 2024 - nature.com
Quantifying the contribution of genetics and environmental effects on disease initiation and
progression, as well as the shared genetics of different diseases, is vital for the …

Fitness consequences of depressive symptoms vary between generations: Evidence from a large cohort of women across the 20th century

CI Gurguis, RA Duckworth, NM Bucaro, C Walss-Bass - Plos one, 2024 - journals.plos.org
Depression has strong negative impacts on how individuals function, leading to the
assumption that there is strong negative selection on this trait that should deplete genetic …

PA-FGRS is a novel estimator of pedigree-based genetic liability that complements genotype-based inferences into the genetic architecture of major depressive …

M Dybdahl Krebs, KL Georgii Hellberg, M Lundberg… - medRxiv, 2023 - medrxiv.org
The state-of-the-field in complex disorder genetics is marked by large-scale, biobank-
ascertained data sets that integrate broad demographic, health, survey, and genetic data …