Applying an evolutionary mismatch framework to understand disease susceptibility
Noncommunicable diseases (NCDs) are on the rise worldwide. Obesity, cardiovascular
disease, and type 2 diabetes are among a long list of “lifestyle” diseases that were rare …
disease, and type 2 diabetes are among a long list of “lifestyle” diseases that were rare …
Epidemiological overview of major depressive disorder in Scandinavia using nationwide registers
JA Pasman, JJ Meijsen, M Haram… - The Lancet Regional …, 2023 - thelancet.com
Background Major depressive disorder (MDD) is a common psychiatric disorder associated
with a high disease burden. This study gives a comprehensive overview of the prevalence …
with a high disease burden. This study gives a comprehensive overview of the prevalence …
Data Resource Profile: Nationwide registry data for high-throughput epidemiology and machine learning (FinRegistry)
E Viippola, S Kuitunen… - International Journal …, 2023 - academic.oup.com
• FinRegistry is a curated, nationwide, register-based data resource for developing statistical
and machine learning models, performing high-throughput epidemiological analyses and …
and machine learning models, performing high-throughput epidemiological analyses and …
Child Mental Health, Family Circumstance, and Long-Term Success: The Effect of Household Income
We use data from a long-running experiment in which American Indian households received
income transfers from a casino, while other households did not. Using a difference-in …
income transfers from a casino, while other households did not. Using a difference-in …
The relationship between genotype-and phenotype-based estimates of genetic liability to human psychiatric disorders, in practice and in theory
Genetics as a science has roots in studying phenotypes of relatives, but molecular
approaches facilitate direct measurements of genomic variation within individuals …
approaches facilitate direct measurements of genomic variation within individuals …
Quantifying the relative importance of genetics and environment on the comorbidity between mental and cardiometabolic disorders using 17 million Scandinavians
Mental disorders are leading causes of disability and premature death worldwide, partly due
to high comorbidity with cardiometabolic disorders. Reasons for this comorbidity are still …
to high comorbidity with cardiometabolic disorders. Reasons for this comorbidity are still …
Diverse environmental perturbations reveal the evolution and context-dependency of genetic effects on gene expression levels
AJ Lea, J Peng, JF Ayroles - Genome Research, 2022 - genome.cshlp.org
There is increasing appreciation that, in addition to being shaped by an individual's
genotype and environment, most complex traits are also determined by poorly understood …
genotype and environment, most complex traits are also determined by poorly understood …
Uncovering the heritable components of multimorbidities and disease trajectories using a nationwide cohort
D Westergaard, FH Jørgensen, J Waaben… - Nature …, 2024 - nature.com
Quantifying the contribution of genetics and environmental effects on disease initiation and
progression, as well as the shared genetics of different diseases, is vital for the …
progression, as well as the shared genetics of different diseases, is vital for the …
Fitness consequences of depressive symptoms vary between generations: Evidence from a large cohort of women across the 20th century
Depression has strong negative impacts on how individuals function, leading to the
assumption that there is strong negative selection on this trait that should deplete genetic …
assumption that there is strong negative selection on this trait that should deplete genetic …
PA-FGRS is a novel estimator of pedigree-based genetic liability that complements genotype-based inferences into the genetic architecture of major depressive …
The state-of-the-field in complex disorder genetics is marked by large-scale, biobank-
ascertained data sets that integrate broad demographic, health, survey, and genetic data …
ascertained data sets that integrate broad demographic, health, survey, and genetic data …