[HTML][HTML] Application of next generation sequencing for diagnosis and clinical management of drug-resistant tuberculosis: updates on recent developments in the field
N Dookie, A Khan, N Padayatchi, K Naidoo - Frontiers in Microbiology, 2022 - frontiersin.org
The World Health Organization's End TB Strategy prioritizes universal access to an early
diagnosis and comprehensive drug susceptibility testing (DST) for all individuals with …
diagnosis and comprehensive drug susceptibility testing (DST) for all individuals with …
Drug re‐engineering and repurposing: A significant and rapid approach to tuberculosis drug discovery
The prevalence of tuberculosis (TB) remains the leading cause of death from a single
infectious agent, ranking it above all other contagious diseases. The problem to tackle this …
infectious agent, ranking it above all other contagious diseases. The problem to tackle this …
Intricate link between siderophore secretion and drug efflux in Mycobacterium tuberculosis
V Meikle, L Zhang, M Niederweis - Antimicrobial Agents and …, 2023 - Am Soc Microbiol
Drug-resistant Mycobacterium tuberculosis is a worldwide health-care problem rendering
current tuberculosis (TB) drugs ineffective. Drug efflux is an important mechanism in …
current tuberculosis (TB) drugs ineffective. Drug efflux is an important mechanism in …
Potential anti-TB investigational compounds and drugs with repurposing potential in TB therapy: a conspectus
AA Adeniji, KE Knoll, DT Loots - Applied microbiology and biotechnology, 2020 - Springer
The latest WHO report estimates about 1.6 million global deaths annually from TB, which is
further exacerbated by drug-resistant (DR) TB and comorbidities with diabetes and HIV …
further exacerbated by drug-resistant (DR) TB and comorbidities with diabetes and HIV …
[HTML][HTML] Acquisition of clofazimine resistance following bedaquiline treatment for multidrug-resistant tuberculosis
Y Liu, J Gao, J Du, W Shu, L Wang, Y Wang… - International Journal of …, 2021 - Elsevier
Objectives We described the prevalence of clofazimine (CFZ) resistance in a multidrug-
resistant tuberculosis (MDR-TB) cohort in China. We also aimed to identify dynamic changes …
resistant tuberculosis (MDR-TB) cohort in China. We also aimed to identify dynamic changes …
Discovery of 1-hydroxy-2-methylquinolin-4 (1H)-one derivatives as new cytochrome bd oxidase inhibitors for tuberculosis therapy
The cytochrome bcc-aa 3 oxidase (Cyt-bcc) of Mycobacterium tuberculosis (Mtb) is a
promising anti-tuberculosis target. However, when Cyt-bcc is inhibited, cytochrome bd …
promising anti-tuberculosis target. However, when Cyt-bcc is inhibited, cytochrome bd …
[HTML][HTML] Clofazimine as a treatment for multidrug-resistant tuberculosis: a review
Multidrug-resistant tuberculosis (MDR-TB) is an infectious disease caused by
Mycobacterium tuberculosis which is resistant to at least isoniazid and rifampicin. This …
Mycobacterium tuberculosis which is resistant to at least isoniazid and rifampicin. This …
Clofazimine: an old drug for never-ending diseases
N Riccardi, A Giacomelli, D Canetti, A Comelli… - Future …, 2020 - Taylor & Francis
Clofazimine (CFZ), an old hydrophobic riminophenazine, has a wide range of
antimycobacterial activity ranging from leprosy to nontuberculous mycobacterial diseases …
antimycobacterial activity ranging from leprosy to nontuberculous mycobacterial diseases …
In Silico Drug Discovery Strategies Identified ADMET Properties of Decoquinate RMB041 and Its Potential Drug Targets against Mycobacterium tuberculosis
KE Knoll, MM van der Walt, DT Loots - Microbiology Spectrum, 2022 - Am Soc Microbiol
The highly adaptive cellular response of Mycobacterium tuberculosis to various antibiotics
and the high costs for clinical trials, hampers the development of novel antimicrobial agents …
and the high costs for clinical trials, hampers the development of novel antimicrobial agents …
Clofazimine for treatment of multidrug-resistant non-tuberculous mycobacteria
HOI Pfaeffle, RM Alameer, MH Marshall… - Pulmonary …, 2021 - Elsevier
Abstract Background:/Question Nontuberculous mycobacteria (NTM) infections are
increasingly detected but difficult to cure given complex drug-resistance patterns. Select US …
increasingly detected but difficult to cure given complex drug-resistance patterns. Select US …