The present invention provides 6-modified bicyclic nucleoside analogs and oligomeric
compounds comprising these nucleoside analogs. In preferred embodiments the nucleoside …

The present invention provides 5'-modi? ed bicyclic nucleo side analogs and oligomeric
compounds comprising at least one of these nucleoside analogs. In preferred embodiments …

5,023,243 A 6, 1991 Tullis 5,034,506 A 7, 1991 Summerton et al. 5,118,800 A 6, 1992 Smith
et al. The present invention provides 6-modified bicyclic nucleo 5,130,302 A 7/1992 …

(63) Continuation-in-part of application No. 1 1/627,964, 5.405, 938 A 4/1995 Summerton et
al. filed on Jan. 27, 2007, now Pat. No. 7,399,845. 5,405,939 A 4/1995 Suhadolnik et al.(60) …

4,828,979 A 5/1989 Klevan et a1_ _ __ 435/6 5,416,016 A 5/1995 Low et al..................
435/240.1 4,835,263 A 5/1989 Nguyen et a1_ 536/27 5,416,203 A 5/1995 …

Oligonucleotide-folate conjugates are described wherein folates are conjugated to one or
more sites on an oligonucleotide including the 2′-, 3′-, 5′-, nucleobase and …

Related US Application Data Gong and Lin," A glassy carbon Supported bilayer lipid-like
mem brane of 5.5-diteradecyl-2-(2-trimethyl-ammonioethyl)-1, 3-(60) Provisional application …

The present disclosure describes bis-modified bicyclic nucleosides and oligomeric
compounds that can be prepared comprising at least one of these bis-modified bicyclic …

5.30303 A 7/1992 Spielvogel et al. including binding affinity. In some embodiments, the
oligo 5,132,418 A 7, 1992 Caruthers et al. meric compounds provided herein hybridize to a …

Oligomeric compounds including oligoribonucleotides and oligoribonucleosides are
provided that have subsequences of 2'-pentoribofuranosyl nucleosides that activate …