Abstract Chagas disease and Human African trypanosomiasis (HAT) are caused by
Trypanosoma cruzi, T. brucei rhodesiense or T. b. gambiense parasites, respectively; while …

Trypanosomatid parasites and fungi cause highly prevalent diseases. Ergosterol plays a
crucial role in the structure and normal function of the membrane of these microorganisms. It …

Chagas' disease (American Trypanosomiasis) is an ancient and endemic illness in Latin
America caused by the protozoan parasite Trypanosoma cruzi. Although there is an urgent …

In searching for new therapeutic agents for treating American trypanosomiasis and Human
African trypanosomiasis, four nitroheterocyclic acylhydrazones of general formulae [R1‐CH …

A series of new ferrocenyl nitroheterocyclic sulfonylhydrazones (1a–4a and 1b–2b) were
prepared by the reaction between formyl (R= H) or acetyl (R= CH3) nitroheterocyclic …

The development of new compounds to treat Chagas disease is imperative due to the
adverse effects of current drugs and their low efficacy in the chronic phase. This study aims …

In the search of new cymantrenyl-and ferrocenyl-sulfonamides as potencial inhibitors of
human carbonic anhydrases (hCAs), four compounds based on N-ethyl or N-methyl …

Four organometallic N-acylhydrazones of the general formulae [M {(η 5-C 5 H 4)-CHdouble
bondNsingle bondNHsingle bondC (O)-(C 5 H 4single bond N)}(CO) 3][(with M= Re (5a) or …

Two new metallocene complexes with formulation [Fe (η 5-C 5 H 5){(η 5-C 5 H 4)-Ndouble
bondCH-2-C 4 H 2 O-(5-C 6 H 4-2-NO 2)}](3) and [Fe (η 5-C 5 H 5){(η 5-C 5 H 4)-Ndouble …

Tuberculosis (TB), a disease caused by Mycobacterium tuberculosis complex, still presents
significant numbers of incidence and mortality, in addition to several cases of drug …