Genetics of rheumatoid arthritis
L Padyukov - Seminars in immunopathology, 2022 - Springer
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease involving symmetric joints
and is generally characterized by persistent pain, tenderness, and destruction of joints. The …
and is generally characterized by persistent pain, tenderness, and destruction of joints. The …
Recent advances in polygenic scores: translation, equitability, methods and FAIR tools
Polygenic scores (PGS) can be used for risk stratification by quantifying individuals' genetic
predisposition to disease, and many potentially clinically useful applications have been …
predisposition to disease, and many potentially clinically useful applications have been …
[HTML][HTML] Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes
Rheumatoid arthritis is a prototypical autoimmune disease that causes joint inflammation
and destruction. There is currently no cure for rheumatoid arthritis, and the effectiveness of …
and destruction. There is currently no cure for rheumatoid arthritis, and the effectiveness of …
Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations
Multiple sclerosis (MS) is a neuro-inflammatory and neurodegenerative disease that is most
prevalent in Northern Europe. Although it is known that inherited risk for MS is located within …
prevalent in Northern Europe. Although it is known that inherited risk for MS is located within …
Global impact of unproductive splicing on human gene expression
Alternative splicing (AS) in human genes is widely viewed as a mechanism for enhancing
proteomic diversity. AS can also impact gene expression levels without increasing protein …
proteomic diversity. AS can also impact gene expression levels without increasing protein …
Meta-analysis fine-mapping is often miscalibrated at single-variant resolution
Meta-analysis is pervasively used to combine multiple genome-wide association studies
(GWASs). Fine-mapping of meta-analysis studies is typically performed as in a single-cohort …
(GWASs). Fine-mapping of meta-analysis studies is typically performed as in a single-cohort …
Dynamic regulatory elements in single-cell multimodal data implicate key immune cell states enriched for autoimmune disease heritability
In autoimmune diseases such as rheumatoid arthritis, the immune system attacks the body's
own cells. Developing a precise understanding of the cell states where noncoding …
own cells. Developing a precise understanding of the cell states where noncoding …
JAK inhibitors for rheumatoid arthritis
S Kubo, S Nakayamada, Y Tanaka - Expert Opinion on …, 2023 - Taylor & Francis
Introduction JAK (Janus kinase) is a type of non-receptor tyrosine kinase that includes JAK1,
JAK2, JAK3, and Tyk2. Currently, there are five JAK inhibitors approved for treating …
JAK2, JAK3, and Tyk2. Currently, there are five JAK inhibitors approved for treating …
Tissue-specific enhancer–gene maps from multimodal single-cell data identify causal disease alleles
Translating genome-wide association study (GWAS) loci into causal variants and genes
requires accurate cell-type-specific enhancer–gene maps from disease-relevant tissues …
requires accurate cell-type-specific enhancer–gene maps from disease-relevant tissues …
Identification of potential drug targets for rheumatoid arthritis from genetic insights: a Mendelian randomization study
Y Cao, Y Yang, Q Hu, G Wei - Journal of translational medicine, 2023 - Springer
Introduction Rheumatoid arthritis (RA) is a chronic inflammatory illness that mostly affects the
joints of the hands and feet and can reduce life expectancy by an average of 3 to 10 years …
joints of the hands and feet and can reduce life expectancy by an average of 3 to 10 years …