Cellular function is controlled through intricate networks of signals, which lead to the myriad
pathways governing cell fate. Fluorescent biosensors have enabled the study of these …

Glucose has long been considered the primary fuel source for the brain. However, glucose
levels fluctuate in the brain during sleep or circuit activity, posing major metabolic stress …

Deciphering the complex interplay between neuronal activity and mitochondrial function is
pivotal in understanding brain aging, a multifaceted process marked by declines in synaptic …

Mental illnesses arise from dysfunction in the brain. Although numerous extraneural factors
influence these illnesses, ultimately, it is the science of the brain that will lead to novel …

As the primary source of norepinephrine (NE) in the brain, the locus coeruleus (LC)
regulates both arousal and stress responses1, 2. However, how local neuromodulatory …

Background Alzheimer's disease (AD) is the most common form of dementia. Although drugs
focusing on reducing amyloid β slow progression, they fail to improve cognitive function …

Postoperative cognitive dysfunction (POCD) is common in the aged population and
associated with poor clinical outcomes. Irisin, an endogenous molecule that mediates the …

Inhibitory neurons shape the brain's computational landscape and rely on different cellular
architectures and intrinsic properties than excitatory neurons. Maintenance of the overall …

Graphical Summary: Binge-like ethanol drinking engages more regions and NAcc inputs in
female relative to male mice. Left: Comparison of regions with both greater c-Fos expression …

Corticostriatal projection neurons from prelimbic medial prefrontal cortex to the nucleus
accumbens core critically regulate drug-seeking behaviors, yet the underlying encoding …