Decoding human cytomegalovirus for the development of innovative diagnostics to detect congenital infection

SM Lawrence, T Goshia, M Sinha, SI Fraley… - Pediatric …, 2024 - nature.com
Cytomegalovirus is the most common cause of congenital infectious disease and the
leading nongenetic etiology of sensorineural hearing loss. Although most infected neonates …

[HTML][HTML] Understanding the Cytomegalovirus Cyclin-Dependent Kinase Ortholog pUL97 as a Multifaceted Regulator and an Antiviral Drug Target

M Marschall, M Schütz, M Wild, E Socher, C Wangen… - Cells, 2024 - mdpi.com
Herpesviral protein kinases, such as the therapy-relevant pUL97 of human cytomegalovirus
(HCMV), are important for viral replication efficiency as well as pathogenesis, and represent …

Apelin, APJ, and ELABELA: role in placental function, pregnancy, and foetal development—an overview

M Dawid, E Mlyczyńska, M Jurek, N Respekta, K Pich… - Cells, 2021 - mdpi.com
The apelinergic system, which includes the apelin receptor (APJ) as well as its two specific
ligands, namely apelin and ELABELA (ELA/APELA/Toddler), have been the subject of many …

[HTML][HTML] Central role of the placenta during viral infection: Immuno-competences and miRNA defensive responses

V Zaga-Clavellina, L Diaz, A Olmos-Ortiz… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Pregnancy is a unique immunological condition in which an “immune-diplomatic” dialogue
between trophoblasts and maternal immune cells is established to protect the fetus from …

Host-viral interactions at the maternal-fetal interface. What we know and what we need to know

JH Girsch, MC Mejia Plazas, A Olivier, M Farah… - Frontiers in …, 2022 - frontiersin.org
In humans, the hemochorial placenta is a unique temporary organ that forms during
pregnancy to support fetal development, gaseous exchange, delivery of nutrition, removal of …

Suppression of human trophoblast syncytialization by human cytomegalovirus infection

N Mimura, T Nagamatsu, K Morita, A Taguchi, T Toya… - Placenta, 2022 - Elsevier
Introduction Placental dysfunction triggers fetal growth restriction in congenital human
cytomegalovirus (HCMV) infection. Studies suggest that HCMV infection interferes with the …

Dipeptidyl peptidase IV inhibition delays developmental programming of obesity and metabolic disease in male offspring of obese mothers

KRC Montaniel, M Bucher, EA Phillips, C Li… - … origins of health and …, 2022 - cambridge.org
Maternal obesity programs the offspring to metabolic diseases later in life; however, the
mechanisms of programming are yet unclear, and no strategies exist for addressing its …

Endothelial cell infection by Guinea pig cytomegalovirus is a lytic or persistent infection depending on tissue origin but requires viral pentamer complex and pp65 …

KY Choi, N El-Hamdi, A McGregor - Journal of Virology, 2022 - Am Soc Microbiol
The guinea pig is the only small animal model for congenital cytomegalovirus (CMV) but
requires species-specific guinea pig cytomegalovirus (GPCMV). Infection of epithelial cells …

Single-nucleus RNA sequencing reveals distinct pathophysiological trophoblast signatures in spontaneous preterm birth subtypes

C Uhm, J Gu, W Ju, S Pizzella, H Oktay, JYC Peng… - Cell & Bioscience, 2025 - Springer
Spontaneous preterm birth (sPTB) poses significant challenges, affecting neonatal health
and neurodevelopmental outcomes worldwide. The specific effects of placental trophoblasts …

[HTML][HTML] 影响山羊产羔数lncRNA 的筛选及功能分析

李耀坤, 许香萍, 陆婷婷, 练志全, 邹娴, 赵智锋… - 畜牧兽医学报, 2020 - html.rhhz.net
旨在分析高, 低繁殖力川中黑山羊卵巢组织中长链非编码RNA (long non-coding RNA, lncRNA)
的表达谱, 探讨lncRNA 与山羊生殖调控的关系, 为解释lncRNA 在山羊繁殖调控中的分子机制 …