Functions and consequences of AID/APOBEC-mediated DNA and RNA deamination
R Pecori, S Di Giorgio, J Paulo Lorenzo… - Nature Reviews …, 2022 - nature.com
The AID/APOBEC polynucleotide cytidine deaminases have historically been classified as
either DNA mutators or RNA editors based on their first identified nucleic acid substrate …
either DNA mutators or RNA editors based on their first identified nucleic acid substrate …
Precision RNA base editing with engineered and endogenous effectors
LS Pfeiffer, T Stafforst - Nature Biotechnology, 2023 - nature.com
RNA base editing refers to the rewriting of genetic information within an intact RNA molecule
and serves various functions, such as evasion of the endogenous immune system and …
and serves various functions, such as evasion of the endogenous immune system and …
The APOBEC protein family: united by structure, divergent in function
JD Salter, RP Bennett, HC Smith - Trends in biochemical sciences, 2016 - cell.com
The APOBEC (apolipoprotein B mRNA editing catalytic polypeptide-like) family of proteins
have diverse and important functions in human health and disease. These proteins have an …
have diverse and important functions in human health and disease. These proteins have an …
The roles of APOBEC-mediated RNA editing in SARS-CoV-2 mutations, replication and fitness
During COVID-19 pandemic, mutations of SARS-CoV-2 produce new strains that can be
more infectious or evade vaccines. Viral RNA mutations can arise from misincorporation by …
more infectious or evade vaccines. Viral RNA mutations can arise from misincorporation by …
EMT and stemness: flexible processes tuned by alternative splicing in development and cancer progression
D Pradella, C Naro, C Sette, C Ghigna - Molecular cancer, 2017 - Springer
Epithelial-to-mesenchymal transition (EMT) is associated with metastasis formation as well
as with generation and maintenance of cancer stem cells. In this way, EMT contributes to …
as with generation and maintenance of cancer stem cells. In this way, EMT contributes to …
[HTML][HTML] Potential APOBEC-mediated RNA editing of the genomes of SARS-CoV-2 and other coronaviruses and its impact on their longer term evolution
J Ratcliff, P Simmonds - Virology, 2021 - Elsevier
Members of the APOBEC family of cytidine deaminases show antiviral activities in
mammalian cells through lethal editing in the genomes of small DNA viruses, herpesviruses …
mammalian cells through lethal editing in the genomes of small DNA viruses, herpesviruses …
RNA editing in the forefront of epitranscriptomics and human health
T Christofi, A Zaravinos - Journal of translational medicine, 2019 - Springer
Post-transcriptional modifications have been recently expanded with the addition of RNA
editing, which is predominantly mediated by adenosine and cytidine deaminases acting on …
editing, which is predominantly mediated by adenosine and cytidine deaminases acting on …
Chemical modifications to RNA: a new layer of gene expression regulation
The first chemical modification to RNA was discovered nearly 60 years ago; to date, more
than 100 chemically distinct modifications have been identified in cellular RNA. With the …
than 100 chemically distinct modifications have been identified in cellular RNA. With the …
Determination of a comprehensive alternative splicing regulatory network and combinatorial regulation by key factors during the epithelial-to-mesenchymal transition
Y Yang, JW Park, TW Bebee… - … and cellular biology, 2016 - Am Soc Microbiol
The epithelial-to-mesenchymal transition (EMT) is an essential biological process during
embryonic development that is also implicated in cancer metastasis. While the …
embryonic development that is also implicated in cancer metastasis. While the …
The role of RNA editing in cancer development and metabolic disorders
Numerous human diseases arise from alterations of genetic information, most notably DNA
mutations. Thought to be merely the intermediate between DNA and protein, changes in …
mutations. Thought to be merely the intermediate between DNA and protein, changes in …