Although the treatment of myocardial infarction (MI) has improved considerably, it is still a
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …

Living cells are constantly exposed to mechanical stimuli arising from the surrounding
extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes …

Rho-associated coiled-coil containing kinases (ROCK) were originally identified as effectors
of the RhoA small GTPase.–They belong to the AGC family of serine/threonine kinases and …

The field of cardiac tissue engineering has made significant strides over the last few
decades, highlighted by the development of human cell derived constructs that have shown …

Reactive oxygen species are the intermediates that are formed during the normal metabolic
process which are effectively neutralized by the antioxidant system of the body. Any …

This study, using mouse embryonic fibroblast (MEF) cells derived from ROCK1−/− and
ROCK2−/− mice, is designed to dissect roles for ROCK1 and ROCK2 in regulating actin …

Background Ras homolog gene family, member A (RhoA)/Rho-associated coiled-coil
forming protein kinase signaling is a key pathway in multiple types of solid organ fibrosis …

The group of AGC protein kinases includes more than 60 protein kinases in the human
genome, classified into 14 families: PDK1, AKT/PKB, SGK, PKA, PKG, PKC, PKN/PRK, RSK …

Ever since the discovery of free radicals, many hypotheses on the deleterious actions of
reactive oxygen species (ROS) have been proposed. However, increasing evidence …

G protein-coupled receptors (GPCRs), such as β-adrenergic and angiotensin II receptors,
located in the membranes of all three major cardiac cell types, ie myocytes, fibroblasts and …