The ligand-stimulated epidermal growth factor receptor (EGFR) has been extensively
studied in the analysis of molecular mechanisms regulating endocytic traffic and the role of …

Ubiquitin acts as a versatile cellular signal that controls a wide range of biological processes
including protein degradation, DNA repair, endocytosis, autophagy, transcription, immunity …

Deubiquitinating enzymes (DUBs) remove ubiquitin (Ub) from Ub-conjugated substrates to
regulate the functional outcome of ubiquitylation. Here we report the discovery of a new …

Ubiquitin-binding domains (UBDs) are modular elements that bind non-covalently to the
protein modifier ubiquitin. Recent atomic-level resolution structures of ubiquitin–UBD …

ARP/wARP is a software suite to build macromolecular models in X-ray crystallography
electron density maps. Structural genomics initiatives and the study of complex …

DNA double-strand breaks (DSBs) not only interrupt the genetic information, but also disrupt
the chromatin structure, and both impairments require repair mechanisms to ensure genome …

Deubiquitinating enzymes (DUBs) are important regulators of ubiquitin signaling. Here, we
report the discovery of deubiquitinating activity in ZUFSP/C6orf113. High-resolution crystal …

Protein dynamics are essential for protein function, and yet it has been challenging to
access the underlying atomic motions in solution on nanosecond-to-microsecond time …

The biological response to DNA double-strand breaks acts to preserve genome integrity.
Individuals bearing inactivating mutations in components of this response exhibit clinical …

Clathrin-mediated endocytosis (CME) is the major pathway of epidermal growth factor
receptor (EGFR) internalization. It is commonly believed that CME mediates long-term …