Susceptibility of human cells to cold stress restricts the use of therapeutic hypothermia and
long-term preservation of organs at low temperatures. In contrast, cells of mammalian …

Abstract Naked mole‐rats (NMRs; Heterocephalus glaber) are among the most hypoxia‐
tolerant mammals. There is evidence that the NMR brain tolerates in vitro hypoxia and NMR …

Despite thousands of neuroprotectants demonstrating promise in preclinical trials, a
neuroprotective therapeutic has yet to be approved for the treatment of acute brain injuries …

Nitric oxide (NO) was one of the key factors to sustain hypoxia-inducible factor-1-α (HIF-1α)
activation during hypoxia. However, the mechanism by which NO production promotes …

Background: Vessel recanalization is the main treatment for ischemic stroke; however, not
all patients benefit from it. This lack of treatment benefit is related to the accompanying …

Many organisms in nature have evolved mechanisms to tolerate severe hypoxia or
ischemia, including the hibernation-capable Arctic ground squirrel (AGS). Although hypoxic …

(1) Background: Abnormal accumulation of extracellular glutamate can occur as dysfunction
of astrocytic glutamate transporters, which has been linked to ischemic brain injury …

Reactive nitrogen species (RNS), including nitric oxide (NO), are important cellular
messengers when tightly regulated, but unregulated production of RNS during hypoxia or …

Studies have shown that some drugs impair spermatogenesis, thereby causing infertility.
Thus, this study aims at investigating the effect of Persea americana seed extract on the …

Hibernating mammals exhibit an innate physiological ability to withstand dramatic
fluctuations in blood flow that occurs during hibernation and arousal or experimental models …