Mitophagy is a selective autophagic process, essential for cellular homeostasis, that
eliminates dysfunctional mitochondria. Activated by inner membrane depolarization, it plays …

Multiple roles for glyceraldehyde-3-phosphate dehydrogenase (GAPDH) have been recently
appreciated. In addition to the cytoplasm where the majority of GAPDH is located under the …

Continuous turnover of intracellular components by autophagy is necessary to preserve
cellular homeostasis in all tissues. Alterations in macroautophagy, the main process …

Fast axonal transport (FAT) requires consistent energy over long distances to fuel the
molecular motors that transport vesicles. We demonstrate that glycolysis provides ATP for …

S-Nitrosylation is a redox-mediated posttranslational modification that regulates protein
function via covalent reaction of nitric oxide (NO)-related species with a cysteine thiol group …

NO and its derivatives can have multiple effects, which impact on neuronal death in different
ways. High levels of NO induces energy depletion-induced necrosis, due to:(i) rapid …

Background New studies provide evidence that glyceraldehyde-3-phosphate
dehydrogenase (GAPDH) is not simply a classical glycolytic protein of little interest. Instead …

Huntington's disease (HD) is a fatal neurodegenerative condition caused by expansion of
the polyglutamine tract in the huntingtin (Htt) protein. Neuronal toxicity in HD is thought to be …

Autophagy as a conserved catabolic pathway can respond to reactive oxygen species
(ROS) and plays an important role in degrading oxidized proteins in plants under various …

Growing evidence points to the fact that glucose metabolism has a central role in
carcinogenesis. Among the enzymes controlling this energy production pathway …