Neglected tropical diseases (NTDs) as termed by WHO include twenty different infectious
diseases that are caused by bacteria, viruses, and parasites. Among these NTDs, Chagas …

Free radicals are often described as chemical compounds characterized by unpaired
electrons in their outer orbital rendering them highly reactive species. In mammalians …

Trypanosoma cruzi is the etiologic agent of Chagas disease, a neglected tropical disease
that affects millions of people mainly in Latin America. To establish a life-long infection, T …

Chagas disease, also known as American trypanosomiasis, is one of the 17 neglected
tropical diseases (NTDs) according to World Health Organization. It is estimated that 8–10 …

Superoxide dismutase (SOD) is a crucial enzyme required to maintain the redox potential of
the cells. It plays a vital role in protecting normal cells from reactive oxygen species (ROS) …

Significance: Chagas disease (CD) affects several million people in Latin America and is
spreading beyond its classical boundaries due to the migration of infected host and insect …

Virulence of Trypanosoma cruzi depends on a variety of genetic and biochemical factors. It
has been proposed that components of the parasites' antioxidant system may play a key part …

Background During Trypanosoma cruzi infection, macrophages produce reactive oxygen
species (ROS) in a process called respiratory burst. Several works have aimed to elucidate …

It has been over a century since Carlos Chagas discovered the Trypanosoma cruzi (T. cruzi)
as the causative agent of Chagas disease (CD), a neglected tropical disease with several …

Trypanosoma cruzi, the causative agent of Chagas disease (CD), contains exclusively Fe-
dependent superoxide dismutases (Fe-SODs). During T. cruzi invasion to macrophages …