The rise of antibiotic resistance necessitates the search for new platforms for drug
development. Prodrugs are common tools for overcoming drawbacks typically associated …

Esterase enzymes are a family of hydrolases that catalyze the breakdown and formation of
ester bonds. Esterases have gained a prominent position in today's world's industrial …

Chemical probes have been instrumental in microbiology since its birth as a discipline in the
19th century when chemical dyes were used to visualize structural features of bacterial cells …

Mycobacterium tuberculosis has a complex life cycle transitioning between active and
dormant growth states depending on environmental conditions. LipN (Rv2970c) is a …

Tuberculosis (TB) is one of the world's most deadly infectious diseases resulting in nearly
1.3 million deaths annually and infecting nearly one-quarter of the population. para …

Human acyl protein thioesterases (APTs) catalyze the depalmitoylation of S‐acylated
proteins attached to the plasma membrane, facilitating reversible cycles of membrane …

The ability of Mycobacterium tuberculosis to derive lipids from the host, store them
intracellularly, and then break them down into energy requires a battery of serine …

Cellular esterases catalyze many essential biological functions by performing hydrolysis
reactions on diverse substrates. The promiscuity of esterases complicates assignment of …

As a class of enzymes, esterases have been investigated for decades and have found use in
industrial processes, synthetic organic chemistry, and elsewhere. Esters are functional …

Phaeodactylum tricornutum is a model oleaginous pennate diatom, widely investigated for
the accumulation of triacylglycerols (TAG) in lipid droplets during nitrogen (N) starvation …