Oral and craniofacial tissues are uniquely adapted for continuous and intricate functioning,
including breathing, feeding, and communication. To achieve these vital processes, this …

Abstract Introduction Orofacial clefts (OFCs) are common craniofacial birth defects with
heterogeneous phenotype and etiology. Geneticists have applied nearly every available …

Perturbations in gene regulation during palatogenesis can lead to cleft palate, which is
among the most common congenital birth defects. Here, we perform single-cell multiome …

The genetic basis of human facial variation and craniofacial birth defects remains poorly
understood. Distant-acting transcriptional enhancers control the fine-tuned spatiotemporal …

Characterising phenotypes often requires quantification of anatomical shape. Quantitative
shape comparison (morphometrics) traditionally uses manually located landmarks and is …

The broad sharing of research data is widely viewed as critical for the speed, quality,
accessibility, and integrity of science. Despite increasing efforts to encourage data sharing …

Excess albumin in enamel is a characteristic of the prevalent developmental dental defect
known as chalky teeth or molar hypomineralization (MH). This study uses proteomic …

Craniofacial disorders arise in early pregnancy and are one of the most common congenital
defects. To fully understand how craniofacial disorders arise, it is essential to characterize …

Epigenetic and chromatin regulation of craniofacial development remains poorly
understood. Ankyrin Repeat Domain 11 (ANKRD11) is a chromatin regulator that has …

Craniofacial development depends on formation and maintenance of sutures between
bones of the skull. In sutures, growth occurs at osteogenic fronts along the edge of each …