Cancer is a prominent cause of death globally. Currently, many drugs that are in clinical
practice are having a high prevalence of side effect and multidrug resistance. Risk of tumors …

Resistance of solid tumors to treatment is significantly attributed to pharmacokinetic reasons
at both cellular and multi-cellular levels. Anticancer agent must be bio-available at the site of …

Multidrug resistance (MDR) is regarded as one of the bottlenecks of successful clinical
treatment for numerous chemotherapeutic agents. Multiple key regulators are alleged to be …

Objective: The genus Ferula L. includes perennial flowering plants belonging to the
Apiaceae family. This genus is a rich source of biologically active phytochemicals such as …

Background: Dual-targeting in cancer treatment by a single drug is an unconventional
approach in relation to drug combinations. The rationale for the development of …

Ferula persica, is the well-known species of the genus Ferula in Iran and has two varieties:
persica and latisecta. They have both been extensively used in traditional medicine for a …

Background Ferula species are reputed in folk medicine for the treatment of a variety of
disorders. There have been sporadic reports on the chemopreventive and chemosensitizing …

In the present study, fifteen sesquiterpene coumarins were isolated and purified from
different Ferula species, and were tested for their MDR reversal properties. Enhancement of …

Ferula species, particularly F. assa-foetida and F. gummosa, have a long history of use in
traditional medicine. They have extensively been used for the treatment of infectious …

Covering: 2011. Previous review: Nat. Prod. Rep. 2011, 28, 1580. This review covers the
isolation, structural determination, synthesis and chemical and microbiological …